Ambrobene solution instructions for use for adults. Ambrobene solution for inhalation: instructions for use. Indications for use of Ambrobene
Ambrobene is sold in several dosage forms:
- solution for oral administration and inhalation;
- syrup;
- capsules;
- pills;
- solution for intravenous administration.
Indications
Ambrobene contains ambroxol as the main substance, which makes the phlegm not so viscous, as a result, it is easier to get out.
In addition, the drug promotes surfactant biosynthesis and prevents the cilia of the bronchial epithelium from sticking together.
Thanks to these properties, Ambrobene can be given to children for diseases of the bronchopulmonary system, in which a lot of thick, viscous sputum is formed, including for diseases such as:
- bronchial asthma;
- acute and chronic inflammation of the bronchi;
- bronchiectasis, in which the bronchi are deformed and their function is impaired;
- pneumonia.
Injections are prescribed to stimulate the formation of surfactant for respiratory distress syndrome in premature and newborn infants.
Instructions for use
The therapy regimen is selected individually depending on the dosage form and the patient's age. The duration of treatment without the permission of the doctor should not exceed 4-5 days. The mucolytic effect of the medication is manifested if you drink a lot of fluids.
The medicine should be drunk after meals.
Solution for inhalation and oral administration
Before drinking the medicine, it can be added to water, juice and tea.
Give Ambrobene in solution to children in the following doses:
Any nebulizer can be used to inhale. Do not use a steam inhaler. Before the procedure, you need to mix saline and mucolytic in equal volumes. The inhaled liquid should be at body temperature.
If the child is asthmatic, it is advisable to do inhalation after taking a bronchodilator.
To do inhalation, the following doses are needed:
During the day, you can do 1 or 2 inhalations.
Syrup
Give Ambrobene syrup to a child in the following dosages:
Capsules
The capsules must be swallowed whole. Teenagers over 12 years old drink them 1 piece per day.
Pills
The tablets must be drunk whole. They need to be taken with a large volume of liquid.
Pill Schedule:
Injection solution
The mucolytic should be injected into the vein slowly in a stream or drip for at least 5 minutes. Ambrobene is added to saline, 5% dextrose solution, Ringer-Locke or other liquids that have a pH value greater than 6.3.
The daily dosage is 30 mg per kg of body weight. It needs to be divided by 4 times. After the acute symptoms of the disease have passed, the drug must be taken orally.
Contraindications
Ambrobene for children in any form of release is impossible with intolerance to its composition.
In addition, the syrup is contraindicated if the child is diagnosed with the following pathologies:
- fructosemia;
- lack of sucrase-isomaltase;
- impaired absorption of galactose and glucose.
Tablets should not be drunk by children under 6 years old, they are also contraindicated if there are the following violations:
- intolerance to milk sugar;
- violation of the adsorption of glucose and galactose;
- hypolactasia.
Capsules are contraindicated in children under 12 years of age.
The drug should be prescribed with caution if the patient has the following diseases:
- recurrence of gastrointestinal ulcers;
- dysfunction of the liver and kidneys;
- dyskinesia of the bronchi and a large accumulation of sputum, which happens with the Sievert-Kartagener triad.
Adverse reactions
Ambrobene can cause the following side effects in a child:
- allergy;
- nausea, vomiting, abdominal pain, indigestion, constipation, taste perversion;
- temperature increase;
- impotence;
- headache;
- dry mouth and throat;
- runny nose;
- dysuria.
If the solution is injected quickly into a vein, it can cause venous edema.
In case of an overdose of Ambrobene, the child may show signs of intoxication:
- excessive agitation;
- stomach upset;
- hypersalivation;
- nausea;
- vomit;
- drop in blood pressure.
If the medicine was taken orally and no more than 2 hours have passed, then the victim is advised to rinse the stomach. The antidote for an overdose with Ambrobene is unknown, so the child is prescribed symptomatic therapy.
Price
How much Ambrobene costs for children depends on the form of release and the pharmacy margin:
Analogues and substitutes
There are many analogues of Ambrobene on sale:
- Ambrohexal;
- Prospan.
Lazolvan or Ambrobene: which is better for inhalation for a child?
The therapeutic effect of Lazolvan is explained by ambroxol. The drug on sale is in ampoules, a solution for inhalation and ingestion, tablets, syrup, lozenges for resorption. The latter can be used by children who have turned 6 years old, they are convenient to take with them and do not need to be washed down with water. Lazolvan syrup is available in 2 dosages of 15 mg and 30 mg in 5 ml, the latter cannot be used for patients under 6 years of age. Lazolvan Max capsules are also on sale, but they can only be from 18 years old.
Lazolvan costs a little more. The rest of the drugs are similar and you can drink any of them.
Is Ambroxol or Ambrobene Better for Children?
Ambroxol is produced by several domestic and foreign companies. It differs from Ambrobene in the composition of auxiliary components and cost. Ambroxol price starts from 30 rubles.
There is no significant difference between Ambroxol and Ambrobene, and after consulting a doctor, the child can be given any of them.
What is better Ambrobene or Ambrohexal for children?
The therapeutic effect of Ambrohexal is explained by Ambroxol. Both drugs have common indications, limitations and undesirable effects. Ambrohexal is not produced in injections. There are no significant differences between medicines, so it is permissible to use any remedy.
What is better for children ACC or Ambrobene?
ACC contains acetylcysteine as the main ingredient. in granules, soluble tablets, syrup, solution for injection into a muscle or vein. Injections under medical supervision can be given from birth. Inside mucolytic is allowed to be taken only by patients over 2 years old. Acetylcysteine helps with purulent sputum. ACC in comparison with Ambrobene has a wider field of application. It is recommended not only for diseases of the respiratory system, but for inflammation of the paranasal sinuses of the nose and middle ear.
But this does not mean that ACC is better than Ambrobene, since it also has contraindications, and it can cause undesirable phenomena, so which remedy should be decided by the doctor, depending on the characteristics of the patient.
What is better to give the child Ambrobene or Gedelix?
Gedelix is a herbal remedy. The healing effect of the medication is due to ivy. On sale, the medicine is in syrup, allowed from birth, and drops, which are possible from 2 years old. They are recommended to be given to children as an expectorant for respiratory diseases, in which a lot of thick, viscous sputum is produced. Gedelix, regardless of the form of release, is contraindicated in case of allergy to its composition, citrullinemia. Drops are prohibited for children with a predisposition to laryngospasm, and they are also prohibited for asthmatics. The herbal mucolytic is usually well tolerated, but sometimes it can cause allergies, nausea, vomiting, diarrhea, and epigastric pain.
It is not very correct to compare Ambrobene and Gedelix, since the drugs have different compositions and limitations, therefore, the doctor should decide which remedy is better individually.
What is better Ascoril or Ambrobene?
This is a combined remedy, therefore, in comparison with Ambrobene, it has more contraindications.
Ascoril should not be for children with hypersensitivity to its composition, high intraocular and blood pressure, thyroid hyperfunction, liver and kidney dysfunction, myocardial inflammation, heart defects, heart rhythm disturbances, bleeding from the stomach, uncompensated diabetes mellitus, exacerbation of gastrointestinal ulcers. Tablets are not allowed for patients who are under 6 years of age.
The combination remedy often causes side effects, but this does not mean that it is worse, it may be it is more suitable.
Is Prospan or Ambrobene preferable for children?
Prospan is an expectorant of herbal origin. The medicine contains ivy as the main component. The medication on sale is in syrup and drops, which are taken orally, and inhalation is also done with them. Prospan has the same indications for use as Ambrobene, but he has other contraindications and negative reactions. Therefore, it is impossible to say which remedy is best for a particular patient.
How to replace Ambrobene for a child should be decided by the doctor depending on the patient's age, the presence of contraindications and the patient's response to therapy.
Reviews
Parents' opinion
On the Internet, there are many positive parental reviews about Ambrobene's medicine. They like the following:
- a wide variety of dosage forms allows you to choose the most suitable one for a particular child;
- the syrup tastes good, which most children like;
- mucolytic is inexpensive;
- the medicine has no age restrictions.
Negative reviews are associated with the fact that Ambrobene sometimes provokes an allergic reaction.
The opinion of Dr. Komarovsky
A well-known pediatrician does not recommend giving expectorant and mucolytic medicines on their own. Only a doctor should prescribe them as part of a comprehensive treatment. Evgeny Olegovich believes that the effectiveness of expectorants in comparison with heavy drinking has not been confirmed. Therefore, in his opinion, if a child has a wet cough, then he should be given as much liquid as possible.
A cough that occurs in a child signals a developing pathology in the body. The main reasons can be infectious and colds developing in the bronchi and lungs. What actions to take, many mothers ask, and what drugs are allowed to treat young children? This especially worries parents of newborns. Today we will consider one of the most effective drugs that help with such ailments - "Ambrobene".
Ambrobene, intended for children, is allowed to be used in the following forms:
- In the form of syrup from 1 month.
- In capsules from 12 years old.
- In tablets from 5 years old.
- In the form of a solution for inhalation from 6 months.
- Drops from birth.
Composition
All types of the drug contain the following components:
- Ambroxol hydrochloride (main active ingredient).
- Titanium dioxide.
- Colloidal silicon precipitated.
- Gelatin.
- Carboxymethylcellulose.
- Iron oxide.
- Triethyl citrate.
Application
- Ambrobene is recommended for babies with dry cough. Such a cough is the most unpleasant and debilitating and, naturally, affects the character of the child. In this case, children become restless, capricious, sleep poorly and sometimes lose their appetite.
- The medicine helps to relieve the main symptoms of this phenomenon, and relief is noticeable after half an hour. Children are advised to take the drug in the form of a syrup. Children love it and it is safe.
- It is recommended to make a sweet solution from the drug in the form of tablets by mixing the medicine with sweet tea or boiled water, and only then give it to the child.
- The medication is convenient to use in inhalation, they also relieve the first symptoms of dry cough, colds and bronchitis well.
When used
- Bronchitis, pneumonia and other prolonged pathological processes in the lungs.
- Helps to improve sputum discharge, which is important for obstructive bronchitis.
- Pediatricians prescribe the drug to premature babies in the first day after birth in order to stop the development of distress syndrome.
- It is used in the case of acute bronchial asthma.
Babies up to a year
For newborns and infants, the drug can only be prescribed by a specialist, and it is allowed to take it only under the supervision of a doctor. Basically, children are admitted to a hospital, after which treatment begins.
For premature newborns, the drug is prescribed necessarily in the prevention of distress syndrome.
Inhalation
- For children under two years of age, use 1 ml twice / 24 hours.
- Children from 2 to 5 are given 1 ml three times a day.
- From 5 to 12 apply 2 ml three times a day.
Solution for inhalation in equal doses is mixed with saline. The liquid temperature should be at room temperature.
Important: during inhalation, ensure a calm and comfortable environment around the baby, do not allow the baby to be capricious.
Syrup
Photo of Ambrobene syrup. Click to enlarge.
Children under one year old are advised to give the remedy in the form of a syrup, it is easier for babies to drink it and it tastes good. The product is available in a glass container with a measuring cup. It is advised to take the medicine during or after meals.
- Up to 2 years old baby(except for newborns and premature babies) offer 0.5 tsp. (2.5 ml) daily.
- From 2 to 5 years, give 0.5 tsp. (2.5 ml) three times a day.
- From five to twelve years old- three times 1 tsp. (5 ml).
- From the age of 12, it is permissible to take the first three days no more than 3 times a day for 2 tsp, then - no more than 2 times a day.
Important: during the treatment of acute bronchitis, the maximum dose is used for the first three days, then it is halved.
Solution
It is convenient to water infants and small children with the solution. It is recommended to dilute the product in a drink and offer the child when he eats.
- Babies up to two years old a dose of 1 ml is recommended twice a day.
- From two to six give 1 ml three times in 24 hours.
- Six to twelve- 2 ml three times a day.
- Children over twelve years old it is allowed to use the drug for the first 2-3 days 2-3 times a day, 4 ml, and then - no more than twice a day.
Pills
It is best for children to buy medicine marked "for children."
Contraindications
- Individual intolerance.
- Epilepsy.
- Lactation period.
- Severe liver disease.
- Renal failure
- Poor bronchial motility.
Side effects
While taking the drug, the following negative reactions may occur:
- Dry mouth.
- Hives, skin rash.
- Diarrhea.
- Constipation.
- Rhinorrhea.
- Contact dermatitis
- Anaphylactic shock (in exceptional cases).
- Nausea.
- Gastralgia.
- Decrease in blood pressure.
The drug should not be taken in conjunction with other similar medications that prevent sputum excretion.
If side effects have been noticed, you should stop taking the drug and consult a doctor.
Overdose
It is important to monitor the condition of the child taking the medication and follow the dosage as instructed. And if suddenly there was an overdose, then follow our instructions and call a doctor.
So, the symptoms of an overdose:
- A sharp deterioration in the child's well-being.
- Vomiting and nausea.
- Increased salivation.
- Lowering blood pressure.
First aid for overdose is as follows:
- Gastric lavage for the first hour and a half
- Give your child any foods that are high in fat.
- Be sure to monitor the condition of the crumbs, in case of deterioration, call a doctor.
Storage and dispensing
All types of the drug, except for syrup, must be stored at temperatures up to 25 degrees
Syrup - 8 to 25 degrees.
"Ambrobene" should be in a dry, closed place inaccessible to children.
The drug is sold without a prescription.
Analogs
"Ambrobene" is allowed to be used from the first days of birth, and this is the main advantage over analogues.
Analogs include:
- "Medox";
- Ambrosan;
- "Lazolvan";
- "Bronchoxol";
- "Flavamed.
The medication, according to many reviews, gives positive results and is very comfortable to use, since it has many forms that are convenient even for the smallest children. Within a few days of use, positive dynamics are noticed and relief comes.
Ambrobene and Lazolvan
There are practically no differences between the drugs, they consist only in excipients and price. You should choose individually, because one thing helps someone, and another helps someone.
Application with other drugs
You can not use the medicine with antitussive drugs: it complicates the removal of sputum, since cough suppression occurs. But "Ambrobene" is often prescribed with antibiotics, for example, "Doxycycline", "Erythromycin", etc. Such combinations are allowed.
1 ml of the drug contains
active substance: ambroxol hydrochloride 7.5 mg,
Excipients: potassium sorbate, hydrochloric acid 25% (for pH correction), purified water
Description
Transparent from colorless to slightly yellowish-brown solution.
Pharmacotherapeutic group
Preparations for eliminating the symptoms of colds and coughs. Expectorant drugs. Mucolytics. Ambroxol.
ATX code R05CB06
pharmachologic effect
Pharmacokinetics
Suction. Absorption is high and almost complete, linearly dependent on the therapeutic dose. The maximum plasma concentration is reached within 1-2.5 hours.
Distribution. Distribution is rapid and extensive, with the highest concentrations in lung tissue. The volume of distribution is approximately 552 liters. The connection with blood plasma proteins is approximately 90%.
Metabolism and excretion. Approximately 30% of the dose taken by mouth undergoes a "first pass" effect through the liver.
CYP3A4 is the main enzyme responsible for the metabolism of ambroxol, under the action of which, mainly in the liver, conjugates are formed.
The half-life is 10 hours. Total clearance: within 660 ml / min, renal clearance is 83% of the total clearance. Excreted by the kidneys: 26% in the form of conjugates, 6% in free form.
Excretion decreases with impaired liver function, which leads to an increase in blood plasma levels by 1.3-2 times, but does not require dose adjustment.
Gender and age do not have a clinically significant effect on the pharmacokinetics of ambroxol and do not require dose adjustment.
Food intake does not affect the bioavailability of Ambroxol hydrochloride.
Pharmacodynamics
Ambrobene® has a secretolytic and expectorant effect; stimulates serous cells of the glands of the bronchial mucosa, increases the content of mucous secretions and the release of a surfactant (surfactant) in the alveoli and bronchi; normalizes the impaired ratio of serous and mucous components of sputum. By activating hydrolyzing enzymes and enhancing the release of lysosomes from Clara cells, it reduces the viscosity of sputum. Increases the motor activity of the cilia of the ciliated epithelium, increases mucociliary transport of sputum. Increasing secretion and mucociliary clearance improves sputum secretion and relieves coughing.
It has been proven that the local anesthetic effect of ambroxol is due to the dose-dependent blockade of the sodium channels of neurons. Under the influence of ambroxol, the release of cytokines from the blood, as well as from tissue mononuclear cells and polymorphonuclear cells, is significantly reduced.
Clinical studies on patients with sore throat have shown significant reductions in sore throat pain and redness.
Indications for use
Secretolytic therapy of acute and chronic bronchopulmonary diseases characterized by impaired secretion and difficult sputum discharge
Method of administration and dosage
Ambrobene® solution for oral administration and inhalation is dosed using the supplied dosage cup. To be taken after meals with a sufficient amount of warm liquid, such as tea or broth:
Adults and children over 12 years old: in the first 2-3 days, 4 ml 3 times a day (equivalent to 90 mg of ambroxol per day), then 4 ml 2 times (equivalent to 60 mg of ambroxol per day).
Children from 6 to 12 years old: 2 ml 2-3 times a day (equivalent to 30-45 mg of ambroxol per day).
Children from 2-5 years old: 1 ml 3 times a day (equivalent to 22.5 mg of ambroxol per day).
The duration of treatment depends on the characteristics of the course of the disease. It is not recommended to use Ambrobene® without a medical prescription for more than 4-5 days.
Side effects
Gastrointestinal Disorders
Often (≥ 1/100 -< 1/10):
Nausea, change in taste, decreased sensitivity in the mouth and pharynx (oral and pharyngeal hyposthesia)
Uncommon (≥ 1/1000 -< 1/100):
Vomiting, diarrhea, indigestion, abdominal pain, dry mouth
Rarely (≥ 1/10000 -< 1/1000):
Dry throat
Immune system disorders
Unknown:
Anaphylactic reactions, including anaphylactic shock
Disorders of the skin and subcutaneous tissue
Rarely (≥ 1/10000 -< 1/1000):
Rash, urticaria
Unknown:
Itching and other hypersensitivity reactions, angioedema.
Contraindications
Hypersensitivity to ambroxol and / or other components of the drug
Severe liver failure
Severe renal failure
I trimester of pregnancy
Children's age up to 2 years
Drug interactions
No clinically significant adverse drug interactions have been reported.
Combined use with antitussive drugs leads to difficulty in sputum discharge against the background of suppressing cough.
Increases penetration and concentration in bronchial secretions of amoxicillin, cefuroxime and erythromycin.
special instructions
Very rare cases of severe skin lesions, such as Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported with ambroxol hydrochloride. They are mainly due to the severity of the underlying disease and concomitant treatment. In addition, at an early stage of Stevens-Johnson syndrome and toxic epidermal necrolysis, patients may show signs of the onset of a non-specific disease, with the following symptoms: fever, pain throughout the body, rhinitis, cough and sore throat. The appearance of these signs can lead to unnecessary symptomatic treatment with cold medications. In the event of skin lesions, the patient is immediately examined by a doctor, and the administration of Ambroxol hydrochloride is discontinued.
If the functional capacity of the kidneys is limited and / or in severe liver diseases, Ambrobene® should be used with extreme caution, reducing the dose used and increasing the time between doses of the drug.
Pregnancy and lactation
Ambroxol hydrochloride crosses the placental barrier. Preclinical studies have not shown direct or indirect adverse effects on pregnancy, fetal development, labor and postnatal development.
It is not recommended to use Ambrobene® during the first trimester of pregnancy. Despite the fact that until now there is no reliable data on the negative effect on the fetus and infants, the use of the drug in the II and III trimesters of pregnancy and during lactation is possible after a thorough analysis of the benefit / risk ratio by the attending physician.
In this article, you can read the instructions for using the medicinal product. Ambrobene... The reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Ambrobene in their practice are presented. A big request is to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, which may not have been declared by the manufacturer in the annotation. Analogs of Ambrobene in the presence of available structural analogs. Use for the treatment of dry cough, thinning and removing viscous sputum with bronchitis, pneumonia in adults, children, as well as during pregnancy and lactation.
Ambrobene- mucolytic and expectorant drug.
Ambroxol (the active substance of the Ambrobene drug) is an active metabolite of bromhexine that improves the rheological properties of sputum, reduces its viscosity and adhesive properties, facilitating its excretion from the respiratory tract.
Ambrobene stimulates the activity of serous cells of the glands of the bronchial membrane, the production of enzymes that break down the bonds between sputum polysaccharides, the formation of a surfactant and directly the activity of the bronchial cilia, preventing them from sticking together.
After oral administration, the therapeutic effect occurs after 30 minutes and lasts for 6-12 hours (depending on the dose taken).
With parenteral administration, the effect of the drug occurs quickly and lasts for 6-10 hours.
Pharmacokinetics
When administered parenterally, Ambrobene quickly penetrates into tissues. The highest concentration is found in the lungs. Ambroxol penetrates the BBB and the placental barrier, is excreted in breast milk. About 90% of ambroxol is excreted in the urine: of which 90% is in the form of metabolites and 10% is unchanged.
Indications
All forms of the drug are used for diseases of the respiratory tract with the release of viscous sputum and difficulty in its discharge:
- acute and chronic bronchitis;
- pneumonia;
- bronchial asthma;
- bronchiectasis;
- as part of complex therapy to stimulate surfactant synthesis in respiratory distress syndrome in premature infants and newborns (injection solution).
Forms of issue
Tablets 30 mg.
Solution for oral administration and inhalation.
Retard capsules 75 mg.
Syrup (children's form of the drug).
Solution for injection (injections in ampoules).
Instructions for use and dosage
The drug should be taken orally after meals with a sufficient amount of liquid (a glass of water, tea or juice).
Pills
Tablets for adults and children over the age of 12 in the first 2-3 days are prescribed 1 tablet 3 times a day (90 mg per day). Subsequently, they switch to a 2-time intake of the drug, 1/2 tablet per day (30 mg per day).
Children aged 6 to 12 years in the first 2-3 days are prescribed 1/2 tablet 2-3 per day (30-45 mg per day). Subsequently, they switch to taking the drug twice a day, 1/2 tablet per day (30 mg per day).
Retard capsules
Retard capsules for adults and children over the age of 12 are prescribed 1 capsule per day (75 mg per day).
Syrup
The syrup should be taken using a measuring cup: 1 ml of syrup contains 3 mg of ambroxol.
Children under 2 years of age are prescribed 2.5 ml of syrup 2 times a day (15 mg per day).
Children aged 2 to 6 years are prescribed 2.5 ml of syrup 3 times a day (22.5 mg per day).
Children aged 6 to 12 years are prescribed the drug 5 ml of syrup 2-3 times a day (30-45 mg per day).
For adults and children over the age of 12, during the first days, 10 ml of syrup 3 times a day (90 mg per day). Subsequently, 10 ml of syrup 2 times a day (60 mg per day).
Ambrobene in the form of a syrup is the most convenient dosage form for the treatment of pediatric patients.
Solution for oral administration and inhalation
Solution for oral administration and inhalation inside should be taken using a measuring cup: 1 ml of solution contains 7.5 mg of ambroxol.
Children under the age of 2 years are prescribed the drug 1 ml of solution 2 times a day (15 mg per day).
Children aged 2 to 6 years are prescribed the drug 1 ml of solution 3 times a day (22.5 mg per day).
Children aged 6 to 12 years are prescribed the drug 2 ml of solution 2-3 times a day (30-45 mg per day).
Adults and adolescents in the first 2-3 days are prescribed 4 ml of solution 3 times a day (90 mg per day). On subsequent days - 4 ml 2 times a day (60 mg per day).
When using Ambrobene in the form of inhalation, use any modern equipment (except for steam inhalation). Before inhalation, the drug should be mixed with 0.9% sodium chloride solution (for optimal air humidification, it can be diluted in a 1: 1 ratio) and heated to body temperature. Inhalation should be carried out in normal breathing mode so as not to provoke cough tremors.
Patients with bronchial asthma should use bronchodilators before inhalation of ambroxol to avoid nonspecific irritation of the airways and their spasm.
Children under the age of 2 years are inhaled 1 ml of the solution 1-2 times a day (7.5-15 mg per day).
Children aged 2 to 6 years are inhaled 2 ml of the solution 1-2 times a day (15-30 mg per day).
Adults and children over the age of 6 years are inhaled 2-3 ml of solution 1-2 times a day (15-45 mg per day).
Injection
The solution for injection should be administered intravenously (slowly by stream or drip). The solvent used is 0.9% sodium chloride solution, 5% dextrose solution, Ringer-Locke's solution or other basic solution with a pH not higher than 6.3.
For children, the drug is usually prescribed in a daily dose at the rate of 1.2-1.6 mg / kg of body weight.
Children under the age of 2 years are prescribed 1 ml (1/2 ampoule) 2 times a day (15 mg per day).
Children aged 2 to 6 years are prescribed 1 ml (1/2 ampoule) 3 times a day (22.5 mg per day).
Children over the age of 6 are prescribed 2 ml (1 ampoule) 2-3 times a day (30-45 mg per day).
Adults are prescribed 1 ampoule 2-3 times a day (30-45 mg per day). In severe cases, the dose can be increased to 2 ampoules 2-3 times a day (60-90 mg per day).
In case of respiratory distress syndrome in newborns and premature infants, the daily dose of the drug is 30 mg and, as a rule, is divided into 4 separate injections.
Injections are stopped after the disappearance of acute manifestations of the disease and are switched to the ingestion of other dosage forms of Ambrobene.
Treatment of children under 2 years of age should be carried out only under the supervision of a physician.
The duration of the course of treatment depends on the characteristics of the course of the disease. It is not recommended to use the drug without a medical prescription for more than 4-5 days.
Side effect
- salivation;
- gastralgia;
- nausea, vomiting;
- diarrhea, constipation;
- dry mouth and respiratory tract;
- rhinorrhea;
- skin rash;
- angioedema of the face;
- breathing disorder;
- temperature reaction with chills;
- contact dermatitis;
- anaphylactic shock;
- weakness;
- headache;
- with intravenous administration - intense headaches, a feeling of fatigue and heaviness in the legs, numbness, increased blood pressure, shortness of breath, hyperthermia, chills.
Contraindications
- peptic ulcer of the stomach and duodenum;
- epileptic syndrome;
- children under 6 years of age (for tablets, retard capsules, injection solution);
- children under the age of 12 (for retard capsules);
- hypersensitivity to the components of the drug.
Application during pregnancy and lactation
Since until now there is no reliable data on the negative effect of ambroxol on the fetus and newborn, it is possible to use Ambrobene during pregnancy, especially in the 1st trimester, and during breastfeeding only if the intended benefit to the mother outweighs the potential risk to the fetus.
Drug interactions
The simultaneous use of Ambrobene with drugs that have antitussive activity (for example, containing codeine) is not recommended due to the difficulty in removing sputum from the bronchi against the background of a decrease in cough.
The simultaneous use of Ambrobene with antibiotics (including amoxicillin, cefuroxime, erythromycin, doxycycline) improves the flow of antibiotics into the pulmonary tract. This interaction with doxycycline is widely used for therapeutic purposes.
Cannot be used for injection of the Ambrobene mixture with solutions having a pH higher than 6.3.
Analogues of the drug Ambrobene
Structural analogues for the active substance:
- AmbroGEXAL;
- Ambroxol;
- Ambroxol Vramed;
- Ambroxol retard;
- Ambroxol-Werte;
- Ambroxol-Vial;
- Ambroxol-Richter;
- Ambroxol-Teva;
- Ambroxol-Hemofarm;
- Ambrolan;
- Ambrosan;
- Ambrosol;
- Bronchoxol;
- Bronchorus;
- Dephlegmin;
- Bronhovern drops;
- Lazolangin;
- Lazolvan;
- Medox;
- Mucobron;
- Neo-Bronchol;
- Remebrox;
- Suprima-kof;
- Fervex for cough;
- Flavamed;
- Haliksol.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.
Ambrobene is a mucolytic drug intended for the treatment of infectious and colds inflammatory diseases of the bronchi and lungs, which are accompanied by inflammation, edema and active production of mucous, purulent or mucopurulent sputum. It is used to treat conditions with dry or wet coughs. The active substance of the drug is ambroxol hydrochloride, which belongs to the group of mucolytic agents and has a secretolytic, expectorant and secretomotor effect. This drug is considered the main drug used to treat tracheobronchitis, pneumonia, and is also part of the complex treatment regimens for chronic and congenital lung diseases: bronchitis, bronchial asthma, pneumonia, bronchiectasis, cystic fibrosis, tuberculosis, pneumoconiosis. Its mechanism of action is based on the normalization of the altered ratio of all sputum components and changes in its physicochemical characteristics.
Pharmacodynamics
The mechanism of action of Ambrobene consists in its pronounced expectorant, secretolytic and secretomotor action of the bronchopulmonary system, anti-inflammatory and weak antioxidant action, as well as secretion, stimulation and blocking of surfactant breakdown and activation of perinatal lung development in the prenatal period. Ambrobene also has an activating effect on the cells of the glands of the epithelium of the mucous membrane of the respiratory system, stimulating the secretion of mucous secretions in the alveoli and bronchi, and stimulates the ciliary activity of the cilia of the epithelium of the bronchopulmonary system. The mechanism of action of Ambrobene is based on the stimulation of enzymes of serous cells of the bronchial glands and an increase in the release of lysosomes and a change as a result of this in the physicochemical properties of sputum, a decrease in its viscosity, which leads to facilitation of its expectoration and to a decrease in cough.
Pharmacokinetics
Ambrobene has excellent absorption from the gastrointestinal tract and has a high absorption capacity. The maximum concentration of the drug in the blood plasma is reached one to two hours after its administration. Ambrobene metabolism occurs in liver cells, where dobramanthranilic acid and glucuronic conjugates are formed. The drug is excreted from the body mainly (90%) by the kidneys.
Ambrobene application
Ambrobene has high efficiency, excellent secretolytic, expectorant and secretomotor effects and is used in acute and chronic diseases of the bronchopulmonary system, accompanied by the formation of viscous, difficult to separate phlegm, as an antitussive agent.
Indications for Ambrobene's use:
- With a dry cough against the background of acute respiratory viral infections and acute respiratory infections;
- With pneumonia;
- In acute obstructive bronchitis, tracheobronchitis;
- With bronchial asthma;
- With bronchiectasis;
- With cystic fibrosis of the lungs;
- For childhood infectious diseases complicated by bronchitis and pneumonia;
- With chronic laryngitis, nasopharyngitis, laryngotracheitis;
- With chronic bronchitis;
- With chronic rhinitis;
- For acute or chronic sinusitis of various etiologies;
- To stimulate the maturation of the lungs in the prenatal period;
- When sanitizing the bronchial tree after surgery or in the preoperative period;
- With pneumoconiosis.
Methods of using Ambrobene
Ambrobene is produced by the company "Merkle GmbH" "ratiopharm", Germany and is available in the form of: solution for inhalation and ingestion, tablets, capsules of prolonged action, solution (for intravenous administration), effervescent tablets and syrup.
Ambrobene syrup is available in tinted glass bottles of one hundred milliliters and contains 30 milligrams of the active substance - ambroxol hydrochloride in 5 milliliters of syrup.
The tablet form of the drug Ambrobene is a tablet containing 30 milligrams of active substance.
The solution for intravenous administration contains 75 milligrams of active substance in 100 milliliters of solution.
The solution for oral administration and inhalation contains 75 milligrams of active substance in 2 milliliters of a solution intended for inhalation.
The extended-release capsules contain 75 milligrams of ambroxol hydrochloride.
Ambrobene for inhalation
The solution for inhalation and oral administration contains 75 milligrams of active substance in 100 milliliters of solution, in vials of 40 and 100 milliliters.
Inhalation Ambrobene solution is used for children over six years old and for adults, two to three milliliters of solution up to two times a day at an average daily dose of 15–45 milligrams per day. For children under two years old, one milliliter of solution is used once or twice a day (7.5-15 milligrams per day). Children from two to six years old - two milliliters of solution once or twice a day, 15-30 milligrams per day. Treatment of children under the age of two is carried out only under the supervision of a doctor.
The inhalation solution is used on any inhalation equipment with the exception of steam inhalers. Before inhalation, the drug is mixed in equal proportions with a 0.9% sodium chloride solution. Inhalations are carried out gently in a normal breathing mode, avoiding deep breaths that can provoke a cough. Patients with bronchial asthma are advised to take Ambrobene inhalation in the stage of incomplete or complete remission, while taking bronchodilator drugs.
Today Ambrobene is one of the safest and most effective medicines for children, with a convenient dosage form for both children and adults and practically has no side reactions. For young children from the age of two, it is used in a convenient dosage for children in syrup and solution.
The main distinguishing feature of Ambrobene for children is that it is able to exert both mucolytic and mucoregulatory effects on the mucous membrane of the baby's bronchopulmonary system, which will help to dilute sputum, facilitate its coughing up and, as a result, reduce and disappear cough. And as a mucoregulator, it stimulates the work of the cilia of the ciliated epithelium of the respiratory system and this improves and accelerates the discharge of sputum.
Ambrobene is a drug that actively affects the consistency of sputum, regulating the physicochemical properties and the ratio of its constituent components. This leads to an improvement in expectoration and evacuation of mucus from the child's respiratory system and a decrease in cough in acute, protracted, congenital and chronic inflammatory diseases of the bronchopulmonary system: bronchitis, bronchial asthma, cystic fibrosis, pneumonia and bronchiectasis. Also, the drug Ambrobene has antioxidant qualities and anti-inflammatory effects, and reduces inflammatory reactions in the tissues of the respiratory tract. Under the influence of Ambrobene, the production of a large amount of immunoglobulins is activated, which leads to the activation of local immunity in the alveoli of the lungs and bronchi, and its moderate antioxidant activity reduces the accumulation of free radicals in the epithelial cells of the bronchopulmonary system and indirectly reduces the inflammatory process.
Ambrobene is used in pediatric practice for the complex treatment of infectious and colds of the bronchopulmonary system, complicated by the inflammatory process: with measles, rubella, mumps, scarlet fever or chickenpox.
Ambrobene children's cough syrup has a pleasant raspberry smell and sweet taste and is currently one of the most effective medicines for the treatment of dry cough, easy to use and dispense. It consists of the main active ingredient - ambroxol hydrochloride, as well as various components: liquid sorbitol, saccharin, propylene glycol, raspberry flavor and purified water, which serve to give the syrup a pleasant taste, the required consistency and aromatization.
The syrup is a colorless liquid, thick in consistency, with a pleasant berry taste, in glass bottles of 100 milliliters made of dark glass and contains 15 milligrams of ambroxol hydrochloride in 5 milliliters of syrup for children.
In pediatric practice, Ambrobene is used in the form of a syrup during or after a meal and is dosed: for children under two years of age, with the exception of newborns and premature babies, 2.5 milliliters no more than twice a day. For children from two to five years old, Ambrobene syrup is prescribed 2.5 milliliters no more than three times a day. Children aged five to twelve years - 5 milliliters no more than three times a day. And for children from twelve years of age to adolescents - 10 milliliters in the first three days of treatment no more than three times a day, then 10 milliliters no more than twice a day.
Ambrobene syrup
A syrup of 15 milligrams in 5 milliliters in adults is used as well as in children over twelve years old and in adolescence - in the first three days of treatment, 10 milliliters, but no more than three times a day, then 10 milliliters no more than twice a day.
But more effective dosages of Ambrobene in adulthood are: oral solution, tablets, extended-release capsules, solution (for intravenous administration) or effervescent tablets.
Ambrobene solution
Ambrobene solution for oral administration is a clear, colorless or slightly yellowish odorless liquid. It is available in dark brown glass vials with a special screw cap and a dropper with a measuring cup included. It consists of: 100 milliliters of solution: the active substance ambroxol hydrochloride 0.75 grams and excipients: potassium sorbate and purified water.
It is taken orally with a measuring cup during or after a meal with a large amount of liquid and is dosed: for children under two years old - one milliliter of solution no more than twice a day. Children from two to six years old - one milliliter of solution no more than three times a day. Children from six to twelve years old - two milliliters of solution no more than three times a day. Children over the age of twelve and adults - 4 milliliters of solution for the first two days are taken no more than three times a day, and then 4 milliliters of solution no more than twice a day.
Ambrobene tablets
The tabletted form of Ambrobene in effervescent form and capsules of prolonged action is used only in adulthood by mouth, during or after a meal
Children are prescribed pills over the age of five, half a tablet no more than three times a day.
In the first three days, adults are prescribed one tablet no more than three times a day, and then one tablet no more than twice a day or half a tablet no more than three times a day.
Ambrobene capsules with prolonged action are gelatin capsules with a colorless body and an opaque dark brown lid. The capsules contain light yellow or white granules of a drug substance - ambroxol hydrochloride and excipients: ethyl acrylate and methacrylic acid, microcrystalline microcelluloses, triethyl citrate, hypromellose and silicon dioxide. They are swallowed without chewing only after a meal, with plenty of liquid.
Ambrobene in capsules for children under the age of twelve is not prescribed. Children over twelve years old and adults take one capsule once a day for no more than five days. The duration of treatment is individual and determined by the attending physician.
Contraindications
Contraindications to the use of Ambrobene are individual intolerance to the active substance of the drug - ambroxol hydrochloride or another auxiliary component that is part of the drug.
A contraindication to taking Ambrobene in any form of release is considered the first trimester of pregnancy, as well as insufficient functional ability of the kidneys, epilepsy, duodenal ulcer and stomach ulcer.
Special instructions and interaction with other drugs
With caution, Ambrobene must be taken by pregnant women up to the twenty-eighth week of pregnancy and during the period of breastfeeding.
It is not recommended to take the drug for liver failure and in combination with drugs that suppress the cough reflex. And with the simultaneous appointment of Ambrobene and antibacterial drugs, the flow of antibiotics into the bronchopulmonary system improves, which contributes to their more active therapeutic effect. A good effect is provided by the complex use of Ambrobene and herbal mucolytic medicines - herbal syrups and breast preparations of medicinal herbs.
Side effects of Ambrobene
Side effects of Ambrobene are allergic reactions caused by individual intolerance to the active substance of the drug - ambroxol hydrochloride or another auxiliary component that is part of any of the dosage forms of the drug. They manifest themselves in the form of allergic skin reactions: itching without the presence of rashes, angioedema, allergic dermatitis or urticaria. In the case of uncontrolled and / or prolonged use of the drug, a sharp deterioration in well-being, a decrease in blood pressure, vomiting, increased salivation, nausea, gastralgia, diarrhea or constipation may occur.
If these symptoms occur, you must stop using Ambrobene and seek advice from your doctor at a medical institution.
Overdose
An overdose of the drug occurs when adult forms of the drug are used in childhood, when Ambrobene is taken in dosages exceeding the established therapeutic dose, or when the drug is cumulated in the body, which occurs when its excretion is impaired in kidney or liver pathology.
Symptoms of an Ambrobene overdose are a sharp deterioration in well-being, a decrease in blood pressure, headache, exanthema, increased salivation, dysuria, gastralgia, nausea or vomiting, heartburn, dry mouth and / or respiratory tract, rhinorrhea or an allergic reaction in the form of allergic dermatitis. In severe cases, Quincke's edema or anaphylactic shock may develop. Special treatment for mild symptoms is not required; it is necessary to stop taking the drug. In severe and moderate forms of overdose, a set of measures is required in a medical institution.
Ambrobene price
Ambrobene is a drug that is widely used in therapeutic, pediatric practice, as well as in otolaryngology for the treatment of diseases of the bronchopulmonary system, which are accompanied by dry or wet cough and is always available in pharmacies. The average price of Ambrobene from "Merkle GmbH" "ratiopharm", Austria in tablets of 100 milligrams is on average from 109 rubles, for fifty milligrams - 129 rubles. Ambrobene syrup from the company "Merkle GmbH" "ratiopharm", Germany 100 milliliters - 131 rubles, and Ambrobene in a solution for inhalation and for oral administration from "Merkle GmbH" "ratiopharm", Germany is 132 rubles. Ambrobene capsules for prolonged action from Merkle GmbH, Austria - 153 rubles.
Ambrobene reviews
Ambrobene is an innovative development of the pharmaceutical company "Merkle GmbH" "ratiopharm", Germany or Austria is currently an effective and popular drug. It is widely used in medical practice as a drug for the treatment of cough in adults and children caused by inflammatory diseases of the bronchi and alveoli, pharynx and larynx, as well as the nasal cavity and its paranasal sinuses.
According to its antitussive action, Ambrobene effectively dilutes the mucous secretion that accumulates in the bronchi and alveoli and thick mucus in the nasopharynx. This excellent effect occurs as a result of a change in the physicochemical structure of the secretion, a change in its viscosity, an improvement in outflow and facilitation of coughing up sputum.
Ambrobene is used to treat cough and is prescribed for inflammatory diseases of the bronchopulmonary system of inflammatory and infectious genesis, which are accompanied by severe dry or wet cough in acute and chronic bronchitis, nasopharyngitis, and laryngotracheitis, acute pneumonia and obstructive bronchitis. It is also widely used in otolaryngology to reduce the viscosity of mucus and is included in the complex treatment regimens for sinusitis and otitis media.
Ambrobene is used in the treatment of protracted inflammatory processes of the respiratory tract and is considered the drug of choice for all chronic and congenital diseases of the bronchopulmonary system in adults and children: cystic fibrosis, bronchiectasis, pneumoconiosis, bronchial asthma and tuberculosis, due to its high safety, minimal occurrence of adverse reactions, excellent efficiency and convenient release form.
Ambrobene is effective and has excellent tolerance even with prolonged use, and is also used for the rehabilitation of the bronchial tree before and after surgery.
The active substance of the Ambrobene drug - ambroxol hydrochloride is an activator of secretion, stimulation and blocking of the breakdown of surfactant, and as a result, it stimulates perinatal lung development and is prescribed for lung maturation in the prenatal period with the threat of termination of pregnancy at a later date.
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