Lamotrigine and diazepex are used together. Diazepex injections: instructions for use. Application during pregnancy and lactation
Diazepex is a drug used for various anxiety, anxiety and depressive conditions. Has a pronounced calming effect.
It is currently used to treat many neurological conditions. Refers to anxiolytics. The active basis of the drug is Diazepam.
Pharmacology and mechanism of action
The drug has anxiolytic, hypnotic, sedative and muscle-relaxing effects. Causes a moderate decrease in blood pressure due to the expansion of the coronary vessels. Helps to increase the threshold of sensitivity to pain. Suppresses paroxysms. Leads to a decrease in the production of gastric juice.
When taking the drug, the action begins in half an hour. The maximum plasma concentration is after 1 hour. Binds to plasma proteins. It is destroyed in the liver, the half-life is 2 days (in the elderly - up to 100 hours).
The basis of the mechanism of action of the drug is that it acts on benzodiazepine receptors. This affects the conduction of the interneurons of the spinal cord. There is an increase in the inhibitory effect of GABA (a mediator of inhibition of all parts of the central nervous system).
These processes lead to inhibition of the subcortical parts of the brain. Thanks to the influence on the limbic system, it reduces fear, emotional stress, anxiety. The effect on the brain stem determines the sedative effect of the drug.
Inhibition of the spinal nerve pathways gives the anticonvulsant effect of Diazepex.
Indications and contraindications for use
Diazeppex is used in the following cases:
The use of Diazepex is contraindicated in the following conditions:
- hypersensitivity;
- shock state;
- acute alcohol poisoning, which caused a weakening of all vital functions of the body;
- the use of narcotic pain medications;
- angle-closure glaucoma;
- chronic obstructive pulmonary disease;
- pregnancy;
- age up to 6 months.
Dosages and dosage regimens
The drug is taken orally. In any case, when calculating the dose, only an individual approach is used. The approximate dosages of Diazpex are as follows:
Overdose and side effects
In case of an overdose, the following reactions occur:
- severe drowsiness and confusion;
- areflexia;
- violation of visual function;
- difficulty breathing up to apnea;
- depression of consciousness (up to the development of a coma).
Elimination of these symptoms is carried out by gastric lavage and forced diuresis. Antidote - Flumazenil.
Taking Diazepex can manifest with the following side effects:
special instructions
The drug is addictive and addictive. With withdrawal syndrome, irritability, anxiety, insomnia, tremors, fear, nausea, hallucinations, and very rarely psychosis may appear.
Influences driving and machine control. Use with caution in case of liver and kidney damage.
During pregnancy and lactation, the drug is used only for health reasons. Diazepex has a severe effect on the fetus (it depresses the baby's nervous system).
Interaction with other medications
Enhances the effect of sedatives. Reception with antidepressants enhances the effect of the latter. Enhances the action.
Contraceptive use (oral) increases the risk of bleeding. Caffeine reduces the sedative effect of Diazepex.
Strengthens the excretion of the drug. Paracetamol, on the contrary, slows down this process.
From the practical experience of doctors and patients
Numerous reviews indicate the effectiveness of the use of Diazepex, but there are nuances, more on that below.
Andrey Pavlovich, neurologist
Inside, i / m, i / v, rectally. The dose is calculated individually depending on the patient's condition, clinical picture of the disease, sensitivity to the drug.
As an anxiolytic drug, it is prescribed orally, 2.5-10 mg 2-4 times a day.
Psychiatry: with neuroses, hysterical or hypochondriac reactions, states of dysphoria of various origins, phobias - 5-10 mg 2-3 times a day. If necessary, the dose can be increased to 60 mg / day. With alcohol withdrawal syndrome - 10 mg 3-4 times a day in the first 24 hours, followed by a decrease to 5 mg 3-4 times a day. Elderly, weakened patients, as well as patients with atherosclerosis at the beginning of treatment - by mouth, 2 mg 2 times a day, if necessary, increase to obtain the optimal effect. Working patients are recommended to take 2.5 mg 1-2 times a day or 5 mg (main dose) in the evening.
Neurology: spastic conditions of central origin in degenerative neurological diseases - by mouth, 5-10 mg 2-3 times a day.
Cardiology and rheumatology: angina pectoris - 2-5 mg 2-3 times a day; arterial hypertension - 2-5 mg 2-3 times a day, vertebral syndrome with bed rest - 10 mg 4 times a day; as an additional drug in physiotherapy for rheumatic pelvispondyloarthritis, progressive chronic polyarthritis, arthrosis - 5 mg 1-4 times a day. As part of the complex therapy of myocardial infarction: initial dose - 10 mg / m, then inside, 5-10 mg 1-3 times a day; premedication in case of defibrillation - 10-30 mg IV slowly (in separate doses); spastic conditions of rheumatic origin, vertebral syndrome - an initial dose of 10 mg IM, then inside, 5 mg 1-4 times a day.
Obstetrics and gynecology: psychosomatic disorders, climacteric and menstrual disorders, preeclampsia - 2-5 mg 2-3 times a day. Preeclampsia - the initial dose is 10-20 mg IV, then 5-10 mg orally 3 times a day; eclampsia - during a crisis - intravenous 10-20 mg, then, if necessary, intravenous stream or drip, no more than 100 mg / day. In order to facilitate labor during the opening of the cervix by 2-3 fingers - i / m 20 mg; in case of premature birth and premature placental abruption - intramuscularly at an initial dose of 20 mg, after 1 hour, the administration of the same dose is repeated; maintenance doses - from 10 mg 4 times to 20 mg 3 times a day. With premature placental abruption, treatment is carried out without interruption - until the fetus ripens.
Anesthesiology, surgery: premedication - on the eve of the operation, in the evening - 10-20 mg orally; preparation for surgery - 1 hour before the start of anesthesia in / m adults - 10-20 mg, children - 2.5-10 mg; introduction to anesthesia - intravenous 0.2-0.5 mg / kg; for short-term narcotic sleep in complex diagnostic and therapeutic interventions in therapy and surgery - IV for adults - 10-30 mg, for children - 0.1-0.2 mg / kg.
Pediatrics: psychosomatic and reactive disorders, spastic states of central origin - prescribed with a gradual increase in the dose (starting with low doses and slowly increasing them to the optimal dose well tolerated by the patient), the daily dose (can be divided into 2-3 doses, with the main one, the largest dose, taken in the evening): inside, it is not recommended to use it for up to 6 months, from 6 months and older - 1-2.5 mg, or 40-200 μg / kg, or 1.17-6 mg / m2, 3- 4 times a day.
Inside, from 1 year to 3 years - 1 mg, from 3 to 7 years - 2 mg, from 7 years and older - 3-5 mg. Daily doses are 2, 6 and 8-10 mg, respectively.
Parenteral, status epilepticus and severe recurrent seizures: children from 30 days to 5 years - IV (slowly) 0.2-0.5 mg every 2-5 minutes up to a maximum dose of 5 mg, from 5 years and older - 1 mg every 2- 5 minutes to a maximum dose of 10 mg; if necessary, the treatment can be repeated after 2-4 hours. Muscle relaxation, tetanus: children from 30 days to 5 years old - i / m or i / v 1-2 mg, from 5 years and older - 5-10 mg, if necessary, a dose can be repeated every 3-4 hours.
For elderly and senile patients, treatment should be started with half the usual dose for adults, gradually increasing it, depending on the achieved effect and tolerance. Parenterally in case of anxiety, it is administered intravenously at an initial dose of 0.1-0.2 mg / kg, injections are repeated every 8 hours until the symptoms disappear, then they switch to oral administration.
With motor excitement, the drug is administered intramuscularly or intravenously 10-20 mg 3 times a day. With traumatic lesions of the spinal cord, accompanied by paraplegia or hemiplegia, chorea - in / m adults at an initial dose of 10-20 mg, children - 2-10 mg.
In case of status epilepticus - i / v at an initial dose of 10-20 mg, subsequently, if necessary, 20 mg i / m or i / v drip. If necessary, intravenous drip (no more than 4 ml) is diluted in 5-10% dextrose solution or 0.9% NaCl solution. To avoid precipitation of the drug, use at least 250 ml of infusion solution, quickly and thoroughly mix the resulting solution.
To relieve severe muscle spasm - intravenous once, or twice 10 mg. Tetanus: the initial dose is 0.1-0.3 mg / kg IV at intervals of 1-4 hours or as an IV infusion of 4-10 mg / kg / day
Name: Diazepex
Diazepam * (Diazepam *)
ATX
N05BA01 Diazepam
Pharmacological group
Composition and form of release
1 tablet contains diazepam 2 or 5 mg; in a blister 10 pcs., in a cardboard box 2 blisters.pharmachologic effect
Pharmacological effects - sedative, hypnotic, muscle relaxant, anxiolytic, anticonvulsant.
It is considered a ligand of benzodiazepine receptors, promotes the liberation of GABA and its participation in synaptic transmission.
Pharmacodynamics
The calming and anti-anxiety effects are due to the influence on the benzodiazepine receptors of the limbic system; muscle relaxant and anticonvulsant - inhibition of spinal reflexes.Indications of the drug Diazepex
Anxiety, anxiety, tension, depression, depression; as a component of complex treatment, it is also used for convulsive syndrome, arterial hypertension, rheumatoid arthritis, lumbago, malignant tumors, menopause, premenstrual syndrome, dysalgomenorrhea, gastric ulcer and duodenal ulcer, skeletal muscle spasticity, alcoholism, consequences of trauma.Contraindications
Hypersensitivity, glaucoma, myasthenia gravis.Application during pregnancy and lactation
Contraindicated in the first trimester of pregnancy; during treatment, you need to suspend breastfeeding.Side effects
Drowsiness, dizziness, weakness, ataxia, headache; rarely - visual impairment, euphoria, jaundice, dry mouth, nausea, constipation, shortness of breath, tachycardia, hypotension, leukopenia, granulocytopenia, allergic reactions.Interaction
The result is enhanced by phenothiazine derivatives, barbiturates, MAO inhibitors, cimetidine, alcohol.Method of administration and dosage
Inside. For states of anxiety and anxiety: 2-5 mg 2-4 times a day. For spastic conditions: 2-10 mg 3-4 times a day. The highest daily dosage for outpatient patients is 15 mg. Children under 3 years old - 1-5 mg, 4-12 years old - 2-10 mg / day, often for 1-3 doses.Overdose
Symptoms: drowsiness, inhibition of reflexes, coma is possible. Treatment: symptomatic. The specific antidote is flumazenil.Precautionary measures
It is prescribed with caution for violations of the functions of the heart, respiration, liver and kidneys, organic brain lesions, elderly patients, children. During the appointment, it is suggested to avoid work associated with risk and speed of reactions.Storage conditions of the drug Diazpex
In a dry place at room temperature.
Keep out of the reach of children.
Shelf life of the drug Diazepex
Do not use after the expiration date printed on the package.
1 tablet contains diazepam 2 or 5 mg; in a blister 10 pcs., in a cardboard box 2 blisters.
pharmachologic effect
pharmachologic effect- hypnotic, sedative, muscle relaxant, anticonvulsant, anxiolytic.It is a ligand of benzodiazepine receptors, promotes the liberation of GABA and its participation in synaptic transmission.
Pharmacodynamics
The calming and anti-anxiety effects are due to the influence on the benzodiazepine receptors of the limbic system; muscle relaxant and anticonvulsant - inhibition of spinal reflexes.
Indications of the drug Diazpex
Anxiety, anxiety, tension, depression, depression; as a component of complex treatment it is also used for convulsive syndrome, arterial hypertension, rheumatoid arthritis, lumbago, malignant tumors, menopause, premenstrual syndrome, dysalgomenorrhea, gastric ulcer and duodenal ulcer, skeletal muscle spasticity, alcoholism, consequences of trauma.
Contraindications
Hypersensitivity, glaucoma, myasthenia gravis.
Application during pregnancy and lactation
Contraindicated in the first trimester of pregnancy; during treatment, it is necessary to suspend breastfeeding.
Side effects
Drowsiness, dizziness, weakness, ataxia, headache; rarely - visual impairment, euphoria, jaundice, dry mouth, nausea, constipation, shortness of breath, tachycardia, hypotension, leukopenia, granulocytopenia, allergic reactions.
Interaction
The effect is enhanced by phenothiazine derivatives, barbiturates, MAO inhibitors, cimetidine, alcohol.
Method of administration and dosage
Inside. For states of anxiety and anxiety: 2-5 mg 2-4 times a day.
For spastic conditions: 2-10 mg 3-4 times a day. The maximum daily dose for outpatients is 15 mg.
Children under 3 years old - 1-5 mg, 4-12 years old - 2-10 mg / day, usually for 1-3 doses.
Overdose
Symptoms: drowsiness, inhibition of reflexes, coma is possible.
Treatment: symptomatic. The specific antidote is flumazenil.
Precautionary measures
It is prescribed with caution for violations of the functions of the heart, respiration, liver and kidneys, organic brain lesions, elderly patients, children. During the reception, it is recommended to avoid work associated with risk and speed of reactions.
Storage conditions of the drug Diazpex
In a dry place at room temperature.Keep out of the reach of children.
Shelf life of the drug Diazepex
5 years.Do not use after the expiration date printed on the package.
Synonyms for nosological groups
| ICD-10 heading | Synonyms of diseases according to ICD-10 |
|---|---|
| F10.2 Alcohol dependence syndrome | Alcoholism |
| Alcohol addiction | |
| Dipsomania | |
| Alcohol addiction | |
| Drunkenness | |
| Drunken state | |
| Alcohol abuse | |
| Ideatorial disorder in alcoholism | |
| Quarter binge | |
| Compulsive alcohol cravings | |
| Neurotic symptoms in alcoholism | |
| Pathological craving for alcohol | |
| Psychoorganic syndrome in chronic alcoholism | |
| Decreased craving for alcohol | |
| Chronic alcoholism | |
| F32 Depressive episode | Adynamic subdepression |
| Astheno-adynamic subdepressive states | |
| Asthenic-depressive disorder | |
| Asthenic-depressive state | |
| Asthenodepressive Disorder | |
| Asthenodepressive state | |
| Major depressive disorder | |
| Lethargic depression with lethargy | |
| Double depression | |
| Depressive pseudodementia | |
| Depressive illness | |
| Depressive mood disorder | |
| Depressive disorder | |
| Depressive mood disorder | |
| Depressive state | |
| Depressive disorders | |
| Depressive syndrome | |
| Larvated depressive syndrome | |
| Depressive syndrome in psychosis | |
| Depression masked | |
| Depression | |
| Depression exhaustion | |
| Depression with symptoms of lethargy in the context of cyclothymia | |
| Depression smiling | |
| Involutionary depression | |
| Involutionary melancholy | |
| Involutionary depressions | |
| Manic-depressive disorder | |
| Masked depression | |
| Melancholic attack | |
| Neurotic depression | |
| Neurotic depression | |
| Shallow depression | |
| Organic depression | |
| Organic depressive syndrome | |
| Simple depression | |
| Simple melancholic syndrome | |
| Psychogenic depression | |
| Reactive depression | |
| Reactive depression with mild psychopathological symptoms | |
| Reactive depressive states | |
| Reactive depression | |
| Recurrent depression | |
| Seasonal depressive syndrome | |
| Senestopathic depression | |
| Senile depression | |
| Senile depression | |
| Symptomatic depression | |
| Somatogenic depression | |
| Cyclothymic depression | |
| Exogenous depression | |
| Endogenous depression | |
| Endogenous depressive conditions | |
| Endogenous depression | |
| Endogenous depressive syndrome | |
| F41 Other anxiety disorders | Relief of anxiety |
| Non-psychotic anxiety disorders | |
| Alarm state | |
| Anxiety | |
| Anxious and suspicious states | |
| Chronic anxiety | |
| Sense of anxiety | |
| G24 Dystonia | Impaired muscle tone |
| I10 Essential (primary) hypertension | Arterial hypertension |
| Arterial hypertension | |
| Arterial hypertension | |
| Sudden increase in blood pressure | |
| Hypertensive condition | |
| Hypertensive crises | |
| Hypertension | |
| Arterial hypertension | |
| Hypertension, malignant | |
| Essential hypertension | |
| Hypertonic disease | |
| Hypertensive crises | |
| Hypertensive crisis | |
| Hypertension | |
| Malignant hypertension | |
| Malignant hypertension | |
| Isolated systolic hypertension | |
| Hypertensive crisis | |
| Primary arterial hypertension | |
| Essential arterial hypertension | |
| Essential arterial hypertension | |
| Essential hypertension | |
| Essential hypertension | |
| I15 Secondary hypertension | Arterial hypertension |
| Arterial hypertension | |
| Arterial hypertension of the crisis course | |
| Arterial hypertension complicated by diabetes mellitus | |
| Arterial hypertension | |
| Renovascular hypertension | |
| Sudden increase in blood pressure | |
| Hypertensive circulatory disorders | |
| Hypertensive condition | |
| Hypertensive crises | |
| Hypertension | |
| Arterial hypertension | |
| Hypertension, malignant | |
| Symptomatic hypertension | |
| Hypertensive crises | |
| Hypertensive crisis | |
| Hypertension | |
| Malignant hypertension | |
| Malignant hypertension | |
| Hypertensive crisis | |
| Exacerbation of hypertension | |
| Renal hypertension | |
| Renovascular arterial hypertension | |
| Renovascular hypertension | |
| Symptomatic arterial hypertension | |
| Transient arterial hypertension | |
| K25 gastric ulcer | Helicobacter pylori |
| Pain syndrome with gastric ulcer | |
| Inflammation of the stomach lining | |
| Inflammation of the gastrointestinal mucosa | |
| Benign stomach ulcer | |
| Exacerbation of gastroduodenitis against the background of peptic ulcer | |
| Exacerbation of peptic ulcer | |
| Exacerbation of gastric ulcer | |
| Organic gastrointestinal disease | |
| Postoperative gastric ulcer | |
| Recurrence of ulcers | |
| Symptomatic stomach ulcers | |
| Helicobacter pylori | |
| Chronic inflammatory disease of the upper gastrointestinal tract associated with Helicobacter pylori | |
| Erosive and ulcerative lesions of the stomach | |
| Erosive lesions of the stomach | |
| Erosion of the gastric mucosa | |
| Peptic ulcer | |
| Stomach ulcer | |
| Ulcerative lesion of the stomach | |
| Ulcerative lesions of the stomach | |
| K26 Duodenal ulcer | Pain syndrome in duodenal ulcer |
| Pain syndrome in gastric ulcer and duodenal ulcer | |
| Disease of the stomach and duodenum associated with Helicobacter pylori | |
| Exacerbation of peptic ulcer | |
| Exacerbation of duodenal ulcer | |
| Peptic ulcer of the stomach and duodenum | |
| Recurrent duodenal ulcer | |
| Symptomatic stomach and duodenal ulcers | |
| Helicobacter pylori | |
| Helicobacter pylori eradication | |
| Erosive and ulcerative lesions of the duodenum | |
| Erosive and ulcerative lesions of the duodenum associated with Helicobacter pylori | |
| Erosive lesions of the duodenum | |
| Duodenal ulcer | |
| Ulcerative lesions of the duodenum | |
| M05 Seropositive rheumatoid arthritis | Arthritis rheumatoid seropositive |
| M54.3 Sciatica | Sciatica |
| Sciatic nerve neuralgia | |
| Sciatic nerve neuritis | |
| M54.4 Lumbago with sciatica | Pain in the lumbosacral spine |
| Lumbago | |
| Lumbar syndrome | |
| Sciatica | |
| N94.3 Premenstrual tension syndrome | Severe premenstrual syndrome |
| Menstrual psychosomatic disorder | |
| Menstrual Syndrome | |
| Premenstrual tension | |
| Premenstrual condition | |
| Premenstrual period | |
| Premenstrual syndrome | |
| Menstrual Syndrome | |
| N95.1 Menopause and climacteric state in women | Atrophy of the mucous membrane of the lower urinary tract due to estrogen deficiency |
| Vaginal dryness | |
| Autonomic disorders in women | |
| Hypoestrogenic conditions | |
| Estrogen deficiency in menopausal women | |
| Dystrophic changes in the mucous membrane in menopause | |
| Natural menopause | |
| Intact uterus | |
| Climax | |
| Climax female | |
| Menopause in women | |
| Climacteric depression | |
| Menopausal ovarian dysfunction | |
| Menopause | |
| Climacteric neurosis | |
| Menopause | |
| Menopause complicated by psychovegetative symptoms | |
| Menopause symptom complex | |
| Climacteric vegetative disorder | |
| Climacteric psychosomatic disorder | |
| Climacteric disorder | |
| Climacteric disorder in women | |
| Climacteric state | |
| Climacteric vascular disorder | |
| Menopause | |
| Menopause is premature | |
| Menopausal vasomotor symptoms | |
| Menopause period | |
| Lack of estrogen | |
| Feeling hot | |
| Pathological menopause | |
| Perimenopause | |
| Menopause period | |
| Postmenopausal period | |
| Postmenopausal period | |
| Postmenopausal period | |
| Postmenopausal period | |
| Premature menopause | |
| Premenopause | |
| Premenopausal period | |
| Tides | |
| Hot flashes | |
| Flushing of the face in menopause and postmenopause | |
| Hot flashes / hot sensations in menopause | |
| Heartbeat during menopause | |
| Early menopause in women | |
| Disorders in the climacteric period | |
| Climacteric syndrome | |
| Vascular complications of menopause | |
| Physiological menopause | |
| Estrogen deficiency states | |
| R25.2 Convulsions and spasms | Pain syndrome with spasms of smooth muscles |
| Pain syndrome with spasms of smooth muscles (renal and biliary colic, intestinal spasm, dysmenorrhea) | |
| Pain syndrome with spasms of smooth muscles of internal organs | |
| Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea) | |
| Painful muscle spasm | |
| Mimic spasms | |
| Muscle spasticity | |
| Muscle spasms | |
| Tetanus muscle cramps | |
| Muscle spasms of central origin | |
| Muscle spastic conditions | |
| Muscle spasm | |
| Neurological contractures with spasms | |
| Night cramps in the limbs | |
| Night cramps in the legs | |
| Night cramps in the calf muscles | |
| Symptomatic convulsive condition | |
| West syndrome | |
| Smooth muscle spasm | |
| Smooth muscle spasm | |
| Vascular smooth muscle spasm | |
| Muscle spasm | |
| Spasm of striated muscles due to organic diseases of the central nervous system | |
| Skeletal muscle spasm | |
| Spasms of smooth muscles of internal organs | |
| Muscle spasms | |
| Skeletal muscle spasms | |
| Spastic conditions of the striated musculature | |
| Spastic pain syndrome | |
| Spastic state of smooth muscles | |
| Skeletal muscle spasticity | |
| Muscle cramp | |
| Convulsions | |
| Calf muscle cramps | |
| Convulsions of central origin | |
| Convulsive state | |
| Convulsive syndrome | |
| Convulsive status in children | |
| Tonic convulsions | |
| The folding knife phenomenon | |
| Cerebral spastic syndrome | |
| R45.1 Anxiety and agitation | Agitation |
| Anxiety | |
| Explosive excitability | |
| Internal excitement | |
| Excitability | |
| Excitation | |
| Acute excitement | |
| Psychomotor agitation | |
| Hyperexcitability | |
| Motor excitement | |
| Relief of psychomotor agitation | |
| Nervous excitement | |
| Restlessness | |
| Night anxiety | |
| Acute stage of schizophrenia with agitation | |
| Acute mental agitation | |
| Paroxysm of excitement | |
| Overexcitation | |
| Increased excitability | |
| Increased nervous irritability | |
| Increased emotional and cardiac excitability | |
| Increased arousal | |
| Mental arousal | |
| Psychomotor agitation | |
| Psychomotor agitation | |
| Psychomotor agitation | |
| Psychomotor agitation in psychosis | |
| Psychomotor agitation of an epileptic nature | |
| Psychomotor paroxysm | |
| Psychomotor seizure | |
| Symptoms of arousal | |
| Symptoms of psychomotor agitation | |
| A state of agitation | |
| State of anxiety | |
| Arousal state | |
| A state of heightened anxiety | |
| The state of psychomotor agitation | |
| States of anxiety | |
| States of excitement | |
| State of anxiety in somatic diseases | |
| State of arousal | |
| Feeling anxious | |
| Emotional arousal | |
| R45.4 Irritability and anger | Outbursts of anger |
| Anger | |
| Dysphoria | |
| Neurosis with increased irritability | |
| Bitterness | |
| Increased irritability | |
| Increased irritability of the nervous system | |
| Irritability | |
| Irritability with neuroses | |
| Irritability in psychopathic disorders | |
| Symptoms of irritability | |
| R45.7 State of emotional shock and stress, unspecified | Exposure to stress factors |
| Exposure to extreme situations | |
| Long-term emotional stress | |
| Mental stress | |
| Occupational stress | |
| Psychological stress in air travel | |
| Psycho-emotional overload and stress | |
| Psycho-emotional stress in stressful situations | |
| Psychoemotional stress | |
| Stressful condition | |
| Stress | |
| Stressful state | |
| Stressful situations | |
| Stressful states | |
| The stresses of everyday life | |
| Chronic stress | |
| Chronic stress |
