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Instructions for the use of "Bidop" and at what pressure it is taken. Bidop instructions for use, contraindications, side effects, reviews Terms and conditions of storage

Result: positive feedback

Gave me panic attacks

Benefits: efficiency, reasonable cost

Disadvantages: Strong side effects

I tried to switch to this medicine from Concor, but our acquaintance did not work. Concor suited me, and the attending physician said that Bidop was better, stronger. It really reduces blood pressure faster and then keeps it in a normal state for a long time, but I was overtaken by its side effects. There was a strange pressing pain in the chest and a feeling of anxiety. In life, I am a calm person and did not suffer from unreasonable panic attacks, but here it was scary to go to the toilet even at night. So I'm going to part with Bidop. It's better to stay with proven drugs. But I do not deny its effectiveness.

Result: negative feedback

I have been accepting for the second year

Advantages: available in pharmacies, helps, price

Disadvantages: no

I have been taking this drug for the second year already. What I like is that the drug acts gradually, rather than abruptly. Relief comes over time. The pill has a delimiter, you can take a half for prevention, which I did before, now I drink a whole one. I want to give advice to those who take the drug or decide to take it as prescribed by a doctor: it is more profitable to buy a large package at a pharmacy, since the difference will be obvious. Personally, I have been buying for a long time exactly 10 mg for 302 rubles 28 tablets. Enough for a little more than a month, since I do not take it every day, sometimes in good weather I feel good all day. The fact that hypertension faded into the background for me.

Result: negative feedback

Fast-acting medicine for the treatment of hypertension

Benefits: Handles the problem well

Disadvantages: not found

I was diagnosed with hypertension three months ago and immediately the doctor prescribed Bidop to be taken on an empty stomach in the morning. The initial dose was half a tablet, after a week the doctor increased the dosage to 10 mg. By the end of the week, I noticed that the blood pressure had stabilized and kept clearly at the level of 12080. I liked the availability of the medicine, so you don't need a prescription form to buy it. The tablets act quickly but gently. Another huge plus of Bidop is that there are practically no side effects from the pills.

Result: neutral feedback

The effect is weak, and even he does not please for a long time

Benefits: Inexpensive, greatly reduced shortness of breath, normalized heart rate

Disadvantages: Ineffective at high pressure and attacks of angina pectoris, acts slowly, after stopping the intake, the achieved effect quickly fades away

Bidop fulfills its functions far from completely. For example, it practically does not reduce blood pressure. I took it for a long time (4 months), in a rather large dose, but even by the end of the treatment, I did not notice a significant difference (used to be 156, it became 148-150). With a pain in my heart, the same story. For the relief of the attacks of angina pectoris themselves, Bidop is unsuitable, for their prevention it is not very suitable. Well, yes, attacks began to occur less often, but not by much. And the pain is still strong. In terms of heart rate equalization, things are a little better. My pulse returned to normal (however, only after 2 months of taking the drug), and did not jump until the end of therapy. Shortness of breath also gave in, somewhere by the end of the first month it became easier and freer to breathe, and by the end of the fourth month I was running and did not choke. I would have been happy with this effect, but alas, I stopped treatment, and for 3-3.5 weeks I again felt an increase in the previously receded symptoms.

"Bidop" is an effective medicine that is prescribed to patients for the treatment of arterial hypertension (hypertension) and coronary heart disease. Doctors may recommend it as a prophylaxis for angina pectoris. The topic of our article: what is "Bidop", instructions for use, at what pressure and how to take it correctly.

Medicinal product "Bidop"

Composition

"Bidop" contains the active ingredient bisoprolol. The manufacturer produces the drug in dosages of 5 and 10 mg. Additional components - lactose, crospovidone, pigments, MCC. Bisoprolol is in the form of a hemifumarate. The tablets have a protective coating.

Release form

"Bidop" is produced in a blister strip packaging. One blister contains 14 tablets. In a cardboard box 1, 2 or 4 blisters.

You can also buy the medicine in a two-layer plastic bag. It contains tablets of 5 and 10 mg.

The drug is released in the form of tablets.

Pharmacodynamics and pharmacokinetics

Important! In a small dosage, the drug blocks beta1-adrenergic receptors, reduces the synthesis of cyclic adenazine monophosphate.

With an increase in the therapeutic dosage, a beta2-adrenergic blocking effect is noted.

When taking bisoprolol, the total peripheral vascular resistance increases on the first day, then normalizes and decreases in the future.

The hypotensive effect is provided as a result of a decrease in the minute blood volume, sympathetic stimulation of peripheral vessels, and a decrease in the activity of the renin-angiotensin-aldosterone system. With the progression of arterial hypertension, a positive effect occurs in 4-5 days, the condition stabilizes after 2 months from the start of treatment.

The antianginal effect is associated with a decrease in myocardial demand for oxygen supply. The antiarrhythmic effect occurs when tachycardia, increased activity of the sympathetic nervous system, and arterial hypertension are eliminated.

If you take the drug in the correct therapeutic dosages, it has a less pronounced effect on the work of internal organs, which contain beta2-adrenergic receptors.

The drug is absorbed in the body by 85%. Food intake does not affect absorption. The maximum level in blood plasma is observed 3 hours after taking the drug. The drug tends to penetrate the placental barrier in a minimal amount. Bisoprolol is metabolized in the liver by 50%, the rest is excreted in the urine.

Indications for use

The drug "Bidop" is prescribed for patients with the following health problems:

1. Essential arterial hypertension. This pathology is characterized by an increase in systolic and diastolic blood pressure in the arteries.
2. Cardiac ischemia. This is myocardial damage of an acute or chronic form. Arterial blood enters the heart muscle in insufficient quantities due to pathological processes in the coronary arteries.
3. Prevention of angina attacks. A characteristic symptom of this disease is pressing soreness in the chest. Paroxysmal pain occurs at different times of the day.

All these diseases require urgent treatment. During therapy, it is important to accurately observe the dosage, take into account all the recommendations of the attending physician.

The drug is an excellent means of preventing angina pectoris.

Contraindications

The drug "Bidop" is not prescribed to patients who have the following pathologies in the anamnesis:

• individual hypersensitivity to bisoprolol, other beta-blockers;
• collapse, cardiogenic shock;
• acute heart failure, pulmonary edema;
• Prinzmetal's angina;
• bradycardia;
• cardiomegaly;
• peripheral circulatory disorders;
• Raynaud's disease;
• metabolic acidosis.

The drug "Bidop" is not prescribed for children and adolescents. With extreme caution, bisoprolol is prescribed to patients with diabetes mellitus, psoriasis, thyrotoxicosis, and liver failure.

The medicine is not prescribed for children and adolescents.

Side effects

Important! From the side of the central nervous system, during the use of the medication, headache and sleep disorders may occur.

Sometimes, with a negative effect of the drug on the central nervous system, a depressive state occurs, consciousness becomes confused, short-term memory loss, asthenia may appear. Some patients observe a decrease in visual acuity, dry eyes.

Side effects from the cardiovascular system may occur. The most serious of them is the development of complete transverse blockade, cardiac arrest. Patients may notice symptoms of arrhythmia, a strong decrease in blood pressure, orthostatic hypotension. There is a high likelihood of angiospasm as a result of impaired peripheral circulation, so the hands and feet become cold, pressing pain occurs in the chest area.

Symptoms of an allergic reaction may appear - hives, skin rashes and itching. Patients have increased sweating, hyperemia of the skin, exanthema, psoriasis. If you take the drug during pregnancy, the fetus stops developing, hypoglycemia, bradycardia occurs.

How to take and at what pressure, dosage

The drug is taken in the morning. The tablets cannot be chewed, divided into two parts. The average dosage is 2.5-5 mg at a time. According to the testimony of a doctor, the dose may increase to 10 mg of bisoprolol once a day. The maximum average daily dose is 20 mg. The drug "Bidop" is prescribed to patients with high blood pressure.

Overdose

If the patient intentionally or accidentally took a large dose of the drug "Bidop", there are symptoms of arrhythmia, ventricular extrasystole. The most common manifestations of an overdose:

• cyanosis;
• labored breathing;
• spasms in the bronchi and lungs;
• dizziness;
• fainting;
• convulsions.

To treat an overdose, the patient is hospitalized in a hospital, the stomach is washed, and adsorbent drugs are prescribed. The main goal of therapy is to relieve symptoms.

Heart failure is a dangerous symptom in case of overdose

Interaction

If you take the drug "Bidop" with drugs that contain iodine, the risk of developing anaphylactic shock increases. After intravenous administration of phenytoin, blood pressure can sharply drop to a critical level.

Note! The clearance of lidocaine and xanthines decreases, their concentration in plasma increases.

The drug "Verapamil" contributes to the mutual potentiation of the effect of taking the drug "Bidop". Adrenomimetics reduce the effectiveness of bisoprolol, so there is no effect of treatment. Before starting therapy, it is important to consult a doctor who will take into account the interaction and relationship of the drug with other medications.

Analogs

There are several effective substitutes that have similar effects:

• "Biol";
• "Biprol"
• Bisoprolol;
• "Bisogram";
• "Concor";
• "Niperten".

All of these drugs have side effects. It is strictly forbidden to independently select analogs so as not to encounter an increase in unpleasant symptoms.

Bidop is an effective medicine that helps to quickly and safely lower high blood pressure. It is important to follow the dosage and recommendations of the attending physician. If you stop taking the drug incorrectly, there is a high likelihood of myocardial infarction, arrhythmias. The dosage of bisopolol is gradually reduced over 10-14 days.

Bidop belongs to a group of drugs that have a selective effect on the human body. The main active ingredient is bisoprolol fumarate. It is able to reduce the need for an excess amount of oxygen required by the myocardium, as well as reduce the pulse rate in a state of physical activity and rest. It is used to diagnose arterial hypertension, coronary heart disease, and also as a preventive measure for angina pectoris. Eating food does not affect the absorption of the drug, which occurs in the digestive tract. It is metabolized by the kidneys, in a small amount by bile.

1. Pharmacological action

Medicinal group:

Selective blocker of beta-1 receptors of adrenaline.

The healing effects of Bidop:

• Decrease in the number of myocardial contractions and its oxygen demand;
• Elimination of myocardial ischemia and factors of arrhythmia;
• Negative dromotropic, chronotropic, inotropic and batmotropic effects;
• Suppression of excitability and conduction of the heart muscle;
• Antiangial.

Peculiarities:

• When treating patients with myocardial insufficiency, an abnormal increase in heart oxygen demand and increased stretching of the heart muscle may occur.

2.indications for use

The drug is used for:

• Elimination of essential arterial hypertension;
• Prevention of angina attacks.

• 5 mg per day with an increase in the dosage of the drug by half with insufficient therapeutic effect.

Application features:

• At the beginning of treatment, it is necessary to systematically measure the level of blood pressure;
• According to the instructions, before using the drug, it is necessary to teach patients to independently measure heart rate, and also inform them about the need to report to the attending physician if its values ​​are less than 50 beats per minute;
• Possibly the appearance of negative symptoms associated with dry eyes in patients wearing contact lenses;
• Smoking can reduce the effectiveness of Bidop.

4. Side effects

Nervous system:

Asthenia, short-term memory loss, dizziness, headaches, paresthesia, depression, anxiety, convulsive syndrome, weakness, sleep disturbances, nightmares and hallucinations, impaired consciousness;

Digestive system:

Or constipation, vomiting, stomach pain, nausea, dry mouth, taste perversion, bile stasis;

Respiratory system:

Difficulty breathing, bronchospasm, nasal congestion;

The cardiovascular system:

Arrhythmias, falling blood pressure, blockade of the cardiac conduction system, chest pain, decreased ability of the myocardium to contract, chronic heart failure, orthostatic hypotension;

Skin lesions:

Rash, exacerbation or appearance of psoriasis-like rashes, itching, redness;

Exchange processes:

Increased activity of AST and ALT, increased concentration of bilirubin and triglycerides, impaired glucose concentration (in patients with diabetes mellitus), increased sweating, hypothyroid conditions;

Musculoskeletal system:

Back pain, joint pain;

Blood system:

Decrease in the number of leukocytes, platelets and granulocytes;

Senses:

Dryness of the mucous membrane of the eyes, blurred vision,;

Reproductive system:

Decreased sex drive and potency;

Baldness, exanthema.

5. Contraindications

6. During pregnancy and lactation

Pregnant women and nursing mothers use the drug is strictly prohibited.

7. Interaction with other medicinal products

Simultaneous use of Bidop with:

Opiates:

Development of dangerous lethargy;

Aminophylline or Verapamil:

Mutual enhancement of efficiency;

Adrenomimetics, xanthine derivatives, NSAIDs, GCS or estrogen-containing drugs:

Weakening of the effectiveness of Bidop;

Coumarins, antihypertensive drugs, non-depolarizing muscle relaxants or Insulin:

Strengthening their effectiveness;

Digitalis preparations:

pathological changes in the rhythm of the heart;

Nimodipine or Nicardipine:

Development of heart failure;

Nicotine, Timola Maleat or Propafenone:

Strengthening the effectiveness of Bidop;

Phenytoin or general anesthetic drugs:

Severe cardiodepression, risk of hypotension;

• anaphylaxis;

Organic nitrates:

A sharp drop in blood pressure;

Reserpine:

Severe lethargy, depression, a sharp drop in blood pressure;

Insulin or other hypoglycemic drugs:

Masking the symptoms of glucose deficiency;

Methyldopa or Amiodarone:

Severe bradycardia, risk of cardiac arrest or blockage of the conduction system;

Clonidine, Nifedipine, Hydrolazine, MAO inhibitors or diuretics:

Dangerous fall in blood pressure;

Antidepressants, sedative drugs, antipsychotics or ethanol-containing drugs:

Depression of the central nervous system;

Rifampicin:

Acceleration of removal of Bidop;

• increasing the concentration of Bidop in the blood.

8. Overdose

Symptoms:

The cardiovascular system:

Arrhythmia, AV block, severe bradycardia and hypotension, ventricular, chronic, cyanosis of the palms;

Respiratory system:

Bronchial spasm;

Nervous system:

Convulsions, dizziness, fainting.

Specific Antidote: None.

Overdose treatment with Bidop:

• Cancellation of the drug;
• Reception of enterosorbents;
• Symptomatic treatment.

Hemodialysis: no data provided.

9. Release form

• Tablets, 2.5 mg or 5 mg or 10 mg - 14, 28 or 56 pcs.

10. Storage conditions

• Complete impossibility of access for children;
• Lack of sunlight and heat sources.

For 3 years.

11. Composition

1 tablet:

• bisoprolol hemifumarate - 5 or 10 mg;
• Excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate, crospovidone, pigment PB 22812 yellow (lactose monohydrate 87%, iron oxide yellow 13%).

12. Terms of dispensing from pharmacies

The drug is dispensed by prescription of the attending physician.

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* Instructions for medical use for Bidop are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USING IT IS NECESSARY TO CONSULT A SPECIALIST

Gedeon Richter - Rus, CJSC Nish Generics Limited / Gedeon Richter RUS, CJSC

Country of origin

Ireland Ireland / Russia Russia

Product group

Cardiovascular drugs

Selective beta1-blocker

Forms of issue

• 14 - blisters (1) - cardboard packs. 14 - blisters (2) - cardboard packs. 14 - blisters (2) - cardboard packs. 14 - blisters (4) - packs of cardboard 14 pcs. - blisters (1) - cardboard packs. 14 pcs. - blisters (2) - cardboard packs. 14 pcs. - blisters (4) - cardboard packs.

Description of the dosage form

• Tablets Tablets are white, oblong, with a score on both sides and the marking "BI" to the left of the score and the number "2.5" to the right of the score on one side.

pharmachologic effect

Selective beta1-blocker without intrinsic sympathomimetic activity, does not have a membrane stabilizing effect. Reduces plasma renin activity, reduces myocardial oxygen demand, decreases heart rate (at rest and during exercise). It has hypotensive, antiarrhythmic and antianginal effects. By blocking beta1-adrenergic receptors of the heart in low doses, it reduces the formation of cAMP from ATP stimulated by catecholamines, reduces the intracellular flow of calcium ions, has a negative chrono-, dromo-, batmo- and inotropic effect, inhibits conductivity and excitability. When the therapeutic dose is exceeded, it has a beta2-adrenergic blocking effect. At the beginning of the drug use, in the first 24 hours, the OPSS increases (as a result of a reciprocal increase in the activity of alpha-adrenergic receptors and the elimination of stimulation of beta2-adrenergic receptors), after 1-3 days, the OPSS returns to the initial one, and with prolonged treatment it decreases. The antihypertensive effect is associated with a decrease in the minute blood volume, sympathetic stimulation of peripheral vessels, a decrease in the activity of the renin-angiotensin system (it is of greater importance for patients with initial renin hypersecretion), restoration of sensitivity in response to a decrease in blood pressure and an effect on the central nervous system. With arterial hypertension, the effect develops after 2-5 days, a stable effect - after 1-2 months. The antianginal effect is due to a decrease in myocardial oxygen demand as a result of a decrease in heart rate and a decrease in contractility, an increase in diastole, and an improvement in myocardial perfusion. By increasing the end-diastolic pressure in the left ventricle and increasing the stretching of the muscle fibers of the ventricles, oxygen demand can increase, especially in patients with chronic heart failure. The antiarrhythmic effect is due to the elimination of arrhythmogenic factors (tachycardia, increased activity of the sympathetic nervous system, increased cAMP content, arterial hypertension), a decrease in the rate of spontaneous excitation of sinus and ectopic pacemakers and a slowdown in AV conduction (mainly in the antegrade and, to a lesser extent, in the retrograde directions) through the AV node) and along additional paths. When used in moderate therapeutic doses, in contrast to non-selective beta-blockers, it has a less pronounced effect on organs containing beta2-adrenergic receptors (pancreas, skeletal muscles, smooth muscles of peripheral arteries, bronchi and uterus) and on carbohydrate metabolism, does not cause delay sodium ions in the body; the severity of atherogenic action does not differ from the action of propranolol.

Pharmacokinetics

Absorption Absorption - 80-90%, food intake does not affect absorption. Cmax in blood plasma is observed after 1-3 hours Distribution Plasma protein binding - 26-33%. Permeability through the BBB and the placental barrier is low. Metabolism and excretion 50% is metabolized in the liver with the formation of inactive metabolites. T1 / 2 - 10-12 hours. About 98% is excreted by the kidneys, of which 50% unchanged, less than 2% with bile.

Special conditions

With care: conducting desensitizing therapy, Prinzmetal angina, hyperthyroidism, type 1 diabetes mellitus and diabetes mellitus with significant fluctuations in blood glucose concentration, 1st degree AV block, renal failure (CC less than 20 ml / min), severe liver dysfunction, psoriasis, restrictive cardiomyopathy, congenital heart defects or heart valve disease with severe hemodynamic disturbances, CHF with myocardial infarction within the last 3 months, strict diet. Application during pregnancy and lactation. During pregnancy, the drug should be recommended for use only if the benefits to the mother outweigh the risk of side effects in the fetus and / or child. Typically, beta-blockers reduce blood flow to the placenta and can affect fetal development. Blood flow in the placenta and uterus should be monitored, as well as the growth and development of the unborn child should be monitored, and in the event of adverse events in relation to pregnancy and / or the fetus, alternative therapeutic measures should be taken. The newborn should be carefully examined after delivery. In the first three days of life, symptoms of bradycardia and hypoglycemia may occur. There are no data on the excretion of bisoprolol in breast milk. Therefore, taking the drug is not recommended for women during breastfeeding. If taking the drug during lactation is necessary, breastfeeding should be discontinued. Do not interrupt treatment with the drug abruptly and do not change the recommended dose without first consulting a doctor, as this may lead to a temporary deterioration in the activity of the heart. Treatment should not be interrupted abruptly, especially in patients with coronary artery disease. If discontinuation of treatment is necessary, the dose should be reduced gradually. At the initial stages of drug treatment, patients need constant monitoring. The drug should be used with caution in the following cases: diabetes mellitus with significant fluctuations in the concentration of glucose in the blood: symptoms of a pronounced decrease in glucose concentration (hypoglycemia) such as tachycardia, palpitations or excessive sweating may be masked; strict diet; desensitizing therapy; AV blockade of the I degree; Prinzmetal's angina; mild to moderate peripheral arterial circulation disorders (at the beginning of therapy, an increase in symptoms may occur); psoriasis (including history). Respiratory system: with bronchial asthma or COPD, the simultaneous use of bronchodilating agents is indicated. In patients with bronchial asthma, an increase in airway resistance is possible, which requires a higher dose of beta2-adrenergic agonists. Allergic reactions: beta-blockers, including the drug, can increase the sensitivity to allergens and the severity of anaphylactic reactions due to the weakening of adrenergic compensatory regulation under the action of beta-blockers. Epinephrine (adrenaline) therapy does not always give the expected therapeutic effect. General anesthesia: when carrying out general anesthesia, the risk of beta-adrenergic blockade should be considered. If it is necessary to discontinue drug therapy before surgery, this should be done gradually, and completed 48 hours before general anesthesia. You should warn the anesthesiologist that you are taking the drug. Pheochromocytoma: in patients with adrenal tumor (pheochromocytoma), the drug can be prescribed only against the background of the use of alpha-blockers. Hyperthyroidism: When treated with the drug, symptoms of hyperthyroidism (hyperthyroidism) may be masked. Influence on the ability to drive vehicles and complex mechanisms. According to the study results, the drug does not affect the ability to drive vehicles in patients with coronary artery disease. However, due to individual reactions, the ability to drive vehicles or work with technically complex mechanisms may be impaired. This should be paid special attention to at the beginning of treatment, after changing the dose, as well as with the simultaneous use of alcohol.

Composition

• 1 tab. bisoprolol fumarate 2.5 mg Excipients: lactose monohydrate - 68.15 mg, microcrystalline cellulose - 16 mg, magnesium stearate - 0.35 mg, crospovidone - 3 mg. bisoprolol hemifumarate 10 mg Excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate, crospovidone, beige PB 27215 pigment (lactose monohydrate 87%, iron oxide red and yellow 13%). bisoprolol hemifumarate 5 mg Excipients: lactose monohydrate, microcrystalline cellulose, magnesium stearate, crospovidone, pigment PB 22812 yellow (lactose monohydrate 87%, iron oxide yellow 13%). bisoprolol fumarate 2.5 mg Excipients: lactose monohydrate - 68.15 mg, microcrystalline cellulose - 16 mg, magnesium stearate - 0.35 mg, crospovidone - 3 mg.

Bidop indications for use

• - arterial hypertension; - IHD: prevention of attacks of stable angina pectoris.

Bidop contraindications

• - shock (including cardiogenic); - collapse; - pulmonary edema; - acute heart failure; - chronic heart failure in the stage of decompensation, requiring inotropic therapy; - AV block II and III degree without an electrostimulator; - sinoatrial blockade; - SSSU; - severe bradycardia (heart rate less than 60 beats / min); - cardiomegaly (without signs of heart failure); - severe arterial hypotension (systolic blood pressure less than 100 mm Hg, especially in myocardial infarction); - severe forms of bronchial asthma and COPD in history - concomitant use of MAO inhibitors (except for MAO type B); - late stages of peripheral circulatory disorders; - Raynaud's disease; - pheochromocytoma (without the simultaneous use of alpha-blockers); - metabolic acidosis; - age up to 18 years (efficacy and safety have not been established);

Bidop dosage

• 10 mg 5 mg

Bidop side effects

• From the side of the central nervous system and peripheral nervous system: infrequently - increased fatigue, weakness, asthenia, dizziness, headache, sleep disorders, depression, anxiety, confusion or short-term memory loss; rarely - hallucinations, myasthenia gravis, nightmares, convulsions (including in the calf muscles), paresthesia in the limbs (in patients with intermittent claudication and Raynaud's syndrome), tremor. From the senses: rarely - visual impairment, decreased secretion of lacrimal fluid, dryness and soreness of the eyes; very rarely - conjunctivitis. From the side of the cardiovascular system: very often - sinus bradycardia, palpitations; often - a pronounced decrease in blood pressure, manifestation of angiospasm (increased impairment of peripheral circulation, cooling of the lower extremities, Raynaud's syndrome); infrequently - orthostatic hypotension, impaired myocardial conduction, AV block (up to the development of complete transverse blockade and cardiac arrest), arrhythmias, weakening of myocardial contractility, the development of chronic heart failure (swelling of the ankles, feet; shortness of breath), chest pain. From the digestive system: often - dryness of the oral mucosa, nausea, vomiting, abdominal pain, constipation or diarrhea; rarely - abnormal liver function (dark urine, yellowness of the sclera or skin, cholestasis), taste changes, hepatitis, increased activity of liver enzymes (ACT, ALT), hyperbilirubinemia, hypertriglyceridemia

Drug interactions

With the simultaneous use of antacids and antidiarrheals, it is possible to reduce the absorption of beta-blockers. With the simultaneous use of antiarrhythmic drugs, a sharp decrease in blood pressure, a decrease in heart rate, the development of arrhythmias and / or heart failure are possible. With the simultaneous use of antihypertensive drugs, an increase in the antihypertensive effect is possible. With the simultaneous use of cardiac glycosides, conduction disturbances are possible. With the simultaneous use of sympathomimetics (including those included in the composition of cough suppressants, nasal drops, eye drops), the effectiveness of bisoprolol decreases. With the simultaneous use of verapamil, diltiazem, a sharp decrease in blood pressure, a decrease in heart rate, the development of arrhythmias and / or heart failure are possible. With the simultaneous use of guanfacine, severe bradycardia, conduction disturbances are possible. With the simultaneous use of insulin, hypoglycemic agents for oral administration, the effect of insulin or other hypoglycemic agents is enhanced (regular monitoring of plasma glucose levels is required). With the simultaneous use of clonidine, severe bradycardia, arterial hypotension, conduction disturbances are possible. In the case of a sudden withdrawal of clonidine in patients receiving bisoprolol, a sharp increase in blood pressure is possible. With the simultaneous use of nifedipine, other calcium channel blockers, dihydropyridine derivatives, the antihypertensive effect of bisoprolol is enhanced. With the simultaneous use of reserpine, alpha-methyldopa, severe bradycardia is possible. With the simultaneous use of rifampicin, a slight decrease in T1 / 2 of bisoprolol is possible. With the simultaneous use of ergotamine derivatives (including agents for the treatment of migraines containing ergotamine), symptoms of peripheral circulatory disorders increase.

Overdose

arrhythmia, ventricular premature beats, severe bradycardia, AV block, marked decrease in blood pressure, chronic heart failure, cyanosis of fingernails or palms, difficulty breathing, bronchospasm, dizziness, fainting, convulsions, hypoglycemia.

Storage conditions

• store in a dry place
• keep away from children
• store in a dark place

Information provided

Among patients of different ages, the proportion of patients with pathology of the heart and blood vessels is growing. One of the most commonly used groups of drugs for their treatment is the group of beta-blockers.

A popular representative of this category of funds is Bidop. The instructions for use contain information about the drug necessary for the doctor and patient.

The described agent selectively blocks beta-adrenergic receptors localized in the myocardium (heart muscle), as well as in the fibers of the cardiac conduction system. The main compound, due to which a negative chronotropic, batmotropic and inotropic effect is realized (a decrease in the frequency of contractions, excitability, as well as the strength of heartbeats) is. As part of Bidop (tablets), judging by the instructions for use, this compound is in the form of a salt - fumarate or hemifumarate.

There are forms of the drug where the content of Bisoprolol fumarate is 5 mg, 10 mg. This is convenient for dispensing medication in a given clinical situation. In addition to Bisoprolol Bidop, analogs (generics) of this drug contain auxiliary compounds.

These include additives such as:

• lactose;
• cellulose;
• magnesium stearate;
• iron oxide.

The content of the first two compounds in one 5-milligram tablet is 135 and 35 mg, respectively. Much less in this dosage form is magnesium stearate, iron oxide. Instructions for use indicate that all of the listed substances stain the Bidop tablet in a lemon or amber-yellow shade with darker specks.

What does the medicine help for?

The drug Bidop is used to treat patients with a cardiac profile. What is known about this medicine at the present stage?

Cardiologists and therapists prefer to prescribe Bidop. The indications for use are numerous. Most often, these tablets are applicable for. So, with a completed myocardial infarction, the described agent is the drug of choice from the first days.

It is believed that the use of a beta-blocker (selective, without intrinsic sympathomimetic activity) reduces the risk of mortality, recurrence, and also improves the prognosis of the disease and life in general. What are the effects of Bidop and its analogues?

1. Chronotropic.
2. Dromotropic.
3. Inotropic.
4. Batmotropic.

Instructions for use for Bidop provides an appointment for atrial fibrillation. This form is called otherwise. The atria contract absolutely irregularly. Bidop, analogs of this agent are shown in the tachysystolic variant, when the ventricular rate exceeds 90 per minute.

Together with cardiac glycosides, beta-blockers are components of frequency-corrective therapy. That is, the rhythm cannot be restored when using Bisoprolol, but the heart rate can be controlled.

What else does Bidop help with? This drug is considered one of the remedies that are effective for extrasystole. It can be used for both supraventricular and ventricular pathology. - heart disease, accompanied by an increase in the size of its cavities due to degenerative processes. Despite the fact that non-selective beta-blockers are more preferable for this pathology, Bidop is prescribed for concomitant bronchospasm. The instructions for use do not contradict this.

The mechanism of action of beta-blockers

Indications

According to the instructions for use of Bidop, its use is limited to two main situations. The first is hypertension. It has long been an integral part of antihypertensive therapy. This is especially true for the combination of hypertension with diabetes mellitus, thyrotoxicosis, ischemic heart disease. In these situations, Bidop effectively deals with symptoms such as:

• high blood pressure;
• accelerated heartbeat ();

From what tablets Bidop can still be prescribed? With neurocirculatory dystonia of the cardiac type, this remedy is necessary, so it can relieve the patient of the heart palpitations syndrome or reduce clinical manifestations.

Ischemic heart disease is considered one of the important indications for the use of Bidop. It can include normal exertional angina. Then the effectiveness of the drug is due to the antianginal effect, which consists in reducing the frequency and severity of shortness of breath, chest pain. In postinfarction cardiosclerosis or in the early period of myocardial infarction, Bidop is indicated to improve the prognosis of the disease, life, as well as to prevent sudden cardiac death and repeated cardiovascular accidents. The medication described should be taken for at least 2 years after these conditions.

The next indication for the use of Bidop is considered to be a violation of the rhythm of the heart. This, Wolff-Parkinson-White syndrome, as well as extrasystole.

Instructions for use

According to the annotation for the use of Bidop, there are features of dosage, use. Situations are described when special control over compliance with the dose of the drug is required.

Also in the instructions for use for Bidop lists the side effects and symptoms of an overdose. Serious attention should be paid to the possibility of their appearance.

How do I take the pills?

Bisoprolol fumarate in Bidop is effective for 24 hours. This means that the drug can be taken once a day. You should not prescribe taking Bidop tablets for lunch and evening.

It is considered optimal to use bisoprolol in the morning. It is at this time of day that the level of catecholamines is highest. The active substance blocks receptors for adrenaline and norepinephrine, realizing its main clinical and pharmacological effects.

Food intake does not have a great value on the bioavailability of the drug. Therefore, according to the instructions for use, Bidop can be drunk both before and after meals. It is not recommended to chew the tablet. It is used completely (or half, a quarter of a tablet), washed down with a sufficient amount of water.

Dosage

Bidop tablets are available with 5 and 10 mg bisoprolol fumarate. But cardiologists and clinical pharmacologists insist that the dose of the drug be titrated, starting from the minimum. That is, it is allowed to start therapy with 1.25 mg of Bidop. This is especially true of the outpatient link - a district therapist or a cardiologist's office in a polyclinic.

Further, the dosage of the drug is titrated to the maximum tolerable. This is monitored by measuring pulse, heart rate, blood pressure and diary. With angina pectoris, as well as after suffering myocardial infarction, the target heart rate is 55-60 beats per minute. It is necessary to try to create such a concentration of the drug in the patient's blood in order to maintain this level of heart rate.

It is impossible to cancel Bidop, analogs quickly and abruptly, since all beta-blockers have a pronounced withdrawal syndrome. It can be manifested by the progression of the picture of angina pectoris, the appearance of life-threatening heart rhythm disturbances, as well as myocardial infarction.

special instructions

Often, patients suffering from hypertension, rhythm disturbances or angina pectoris, postinfarction cardiosclerosis may have concomitant liver or kidney damage with severe impairment of their functions.

Instructions for use in these situations provide for a prohibition and restriction on increasing the daily dose of the drug by more than 10 mg. This is not recommended due to the high risk of side effects or adverse events.

In elderly patients, when adjusting the dosage, one should be guided only by the results of the study of electrocardiography, cardiorhythmographic studies, as well as the diaries of the pulse, pressure. Do not change the dose due to the patient's age.

Side effects

Most often, adverse reactions develop due to improper dosing, titration of the dose of the drug Bidop. Side effects are often manifested by symptoms of the central or peripheral nervous system. It can be depression, asthenia and unmotivated weakness. A low mood background can bring very serious discomfort to the patient and his environment, as well as contribute to a decrease in the quality of life, social maladjustment.

On the part of the mental sphere, when using Bidop, according to the instructions for use, the following manifestations are possible:

• crazy ideas;
• hallucinations;
• nightmares in a dream;
• insomnias and dyssomnias are various sleep disorders.

Side effects of Bidop are serious on the part of the cardiovascular system. Beta-blockers are used for cardiac arrhythmias, but at the same time they themselves disrupt the process of conducting a cardiac impulse through the conducting system. This becomes the pathogenetic mechanism for the development of various blockages. The most dangerous is the atrioventricular and sinoauricular blockade. They cause pauses in the work of the heart and fit into the picture of sinus node dysfunction. The appearance of such electrical changes in the heart dictates the need to discontinue the drug.

What other undesirable consequences does Bidop cause? Side effects from the endocrine system are disorders of carbohydrate metabolism. Moreover, these changes are multidirectional for the same pathologies, if you carefully read the instructions for use for Bidop. So, with insulin-dependent diabetes, hypoglycemic states occur, and with diabetes compensated by oral hypoglycemic agents, hyperglycemia occurs. From other endocrinopathies, when taking the drug according to the instructions for use of Bidop, hypothyroidism appears.

From the side of the digestive system usually appear:

• nausea syndrome;
• vomit;
• hepatomegaly (enlarged liver);
• diarrhea.

Constipation sometimes occurs. Allergic reactions are also possible.