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Instructions for the use of Pimafucin® tablets. Pimafucin suppositories, tablets, cream - instructions for use and reviews Pimafucin what is it for

Well established as an antifungal agent used to combat intestinal candidiasis, as well as other infectious lesions. The absence of overdose, drug interactions, as well as the relative absence of contraindications and side effects ensure a comfortable use of the drug. The active ingredient of the drug is natamycin. The medication can be taken by pregnant and lactating women, as well as children.

Dosage form

One of the forms of release of the medication are enteric-coated tablets. Drug units are packaged in 20 pieces. in brown glass bottles, which are closed with a metal lid. Then each bottle is packed in a cardboard box, where the instructions for the product are also placed.

Description and composition

The tablets are white or almost white in color, have a round shape.

In the composition of the drug, natamycin is present as an active component.

Excipients are represented by the following:

• potato starch;
• polyvinylpyrrolidone;
• magnesium stearate;
• lactose.

A number of components are also present in the tablet shell, these include:

• cellulose acetate phthalate;
• triacetin;
• sucrose;
• methyl parahydroxybenzoate;
• calcium carbonate;
• talc;
• kaolin;
• titanium dioxide;
• gum arabic;
• gelatin;
• opaglos 6000.

Pharmacological group

The drug is aimed at the manifestation of fungicidal action. This drug belongs to the tetraene antibiotics of a number of macrolides.

The active ingredient of the tablets binds to the ergosterol of the fungal cell membrane. This provokes its destruction.

Molds and yeasts of the following categories are susceptible to the effect that natamycin produces: Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium... Dermatophytes show less sensitivity, as well as Pseudoallescheria boydii.

There is practically no absorption from the gastrointestinal tract. This explains the lack of systemic influence.

Indications for use

Means in the form of tablets are widely used in therapeutic practice to combat fungal infections provoked by organisms that are sensitive to the active ingredient of the drug.

for adults

Tablets are prescribed for adult patients with:

• intestinal candidiasis;
• pseudomembranous and atrophic candidiasis of acute course in patients with immunodeficiency, cachexia;
• rehabilitation of the intestines with candidiasis of the skin and mucous membranes (including with candidiasis vaginitis, vulvitis and vulvovaginitis);
• pseudomembranous and atrophic candidiasis of acute course after treatment with antibiotics, corticosteroids and cytolytics.

for kids

The drug is used in childhood for the same indications that exist for adult patients.

The list of indications for use in pregnant women, as well as in women during the lactation period, coincides with the list of diseases for which the drug is prescribed for adults.

Contraindications

The only contraindication to the use of the drug in tablets is the patient's special sensitivity to the components of the drug.

Applications and doses

The product is intended for oral administration. After the disappearance of the clinical manifestations of the infectious lesion, doctors recommend continuing to use the drug for several days.

for adults

To combat intestinal candidiasis, adults take one tablet 4 times a day for seven days.

In the case of vaginitis, the appearance of which was provoked by the influence of fungi of the genus Candida, taking tablets is combined with drugs of local antifungal action, and the course of therapy is increased to 10-20 days, while leaving the regimen the same (1 tablet 4 times a day).

for kids

To combat intestinal candidiasis, children are prescribed 1 unit of the drug twice a day.

for pregnant women and during lactation

As a rule, the regimen of taking the drug by pregnant and lactating women remains the same, however, you should consult in detail with your doctor and get additional recommendations.

Side effects

The medication has a small number of side effects. While taking the pills, you may experience a feeling of nausea or intestinal upset. These unpleasant symptoms usually occur in the first days of using the drug. During therapy, they go away on their own.

Interaction with other medicinal products

There were no cases of drug interactions between the drug and other medications.

special instructions

There is no information on the effect of alcohol consumption on the action of the remedy.

The drug in the form of tablets does not affect the ability of people to drive vehicles of any type, as well as high-precision mechanisms, work with which requires an increased concentration of attention, as well as a high speed of psychomotor reactions.

Overdose

Due to the low level of absorption of the drug, an overdose of this drug is recognized as extremely unlikely. To date, no cases of clinical manifestations due to the use of the drug in excessive doses have been described.

Storage conditions

Storage of tablets must be carried out in a place reliably protected from sunlight at a temperature not exceeding 25 ° C.

From the moment of release, the drug is valid for 4 years. After the specified period, the use of the drug should not be carried out.

Dispensing from pharmacies is carried out without a prescription.

Analogs

There are a number of drugs on the pharmaceutical market that can have an effect similar to that produced by use. These include the following drugs:

• Ketozoral (tablets for the treatment of dermatophytosis and folliculitis caused by Melassezia

vaginal suppositories; enteric-coated tablets; cream.

Composition:

Vaginal suppositories. 1 suppository contains: natamycin 100 mg.
Enteric-coated tablets. 1 tablet contains: natamycin 100 mg.
Cream. 1 g of cream contains: natamycin 20 mg.

Description:
Vaginal suppositories: torpedo-shaped, color from white to pale yellow;
Enteric-coated tablets: White round film-coated tablets.
Cream: homogeneous cream of light shade.

Pharmacological properties

Pharmacodynamics. Antifungal polyene antibiotic from the macrolide group with a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms. Most pathogenic yeasts are sensitive to natamycin, especially Candida albicans. Dermatophytes are less sensitive to natamycin. Resistance to natamycin does not occur in clinical practice. Natamycin in tablets, due to the enteric coating, acts only in the intestine.
Pharmacokinetics. Natamycin is not absorbed from the gastrointestinal tract, through intact skin and mucous membranes.

Indications for use
fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug, including:

• acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after therapy with antibiotics, corticosteroids, cytostatics;
• otomycosis, otitis externa, either primarily caused by fungi, or complicated by candidiasis;
• candidiasis of the skin and nails;
• intestinal candidiasis;
• vaginitis, vulvitis, vulvovaginitis, balanoposthitis, caused mainly by fungi Candida;
• dermatomycosis.

Contraindications
Hypersensitivity to the components of the drug.

Method of administration and dosage.
With intestinal candidiasis, adults are prescribed 1 tab. 4 times / day on average within 1 week. Children are prescribed 1 tab. 2 times / day
With dermatomycosis (including candidiasis of the skin and nails, diaper rash in children) the cream is applied to the affected surface of the skin and nails 1 or several times a day.
With otomycosis the affected surface is smeared with cream 1 or several times a day. Before using the drug, the ear is cleaned. After applying the drug, a turunda made of natural material (cotton, wool) is placed in the ear canal.

With vaginitis, vulvitis, vulvovaginitis appoint 1 vaginal suppository for 3-6 days. The suppository is inserted into the vagina in the supine position, as deep as possible, 1 time / day. at night. With a persistent course of vaginitis caused Candida albicans, additionally appoint tablets inside (1 tab. 4 times / day for 10-20 days) to sanitize the focus of candidal infection in the intestine. For the treatment of candidal lesions of the partner's genitals, Pimafucin® is used in the form of a cream.

With balanoposthitis the cream is applied to the affected skin one or more times a day. The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several more days.

Interaction with other medicinal products
The drug interaction of the drug Pimafucin is not described.

Special instructions. Vaginal suppositories under the influence of body temperature quickly dissolve, forming a foamy mass, which contributes to the uniform distribution of the active substance. In the case of a chronic or recurrent infection, topical treatment can be supplemented with pills and a cream. Ethanol, which is part of vaginal suppositories, can cause hypersensitivity reactions. During menstruation, suppository therapy is interrupted. During the period of treatment with suppositories, there is no need to exclude sexual intercourse. However, it is recommended to conduct an examination of the sexual partners and, if a candidal lesion is detected, to conduct a course of treatment with Pimafucin. You should also provide for the use of barrier contraceptives during the treatment period.

Pimafucin® can be administered to newborns.

Pregnancy and lactation. It is possible to use Pimafucin during pregnancy and lactation.

Side effect.
From the gastrointestinal tract: nausea and diarrhea are possible (arising in the first days of taking the pills and passing on their own during treatment). Local reactions: possible slight irritation, burning sensation (when applying cream, vaginal suppositories).

Overdose of the drug. Currently, no cases of overdose of Pimafucin® have been reported.

Storage conditions. The drug should be stored at a temperature of 15 to 25 ° C out of the reach of children.

Shelf life. The shelf life of tablets and cream is 4 years. Shelf life of vaginal suppositories is 2 years. Do not use after the expiration date.

Release form:

enteric-coated tablets, 100 mg, in a bottle 20 tab. Vaginal suppositories 100 mg in blister 3 pcs. Cream 2% in a tube of 30 g.

Pimafucin is intended to relieve the symptoms of thrush and prevent recurrence of its disease. The drug is fast acting. Relief of the condition occurs on the second day of treatment.

Pimafucin is available in the form of tablets, suppositories and cream. Preparations of different forms of release can be combined in one therapeutic course.

The high degree of effectiveness of the drug is provided by the substances that make up its composition. The components not only eliminate the manifestation of thrush, but also have a detrimental effect on the causative agent of the infection.

The drug is safe and approved for use at any stage of pregnancy. In some cases, a medication is prescribed for the complex treatment of both partners.

1. Instructions for use

A detailed scheme for using different forms of Pimafucin release is described in the instructions. The duration of the course depends on the severity of thrush and the form of the disease. The manufacturer offers information on indications, contraindications, possible side effects and the nuances of combining the drug with drugs of other groups for review. Additionally, the instructions contain special instructions (this point should be paid attention to in the presence of serious pathologies or chronic diseases).

pharmachologic effect

Pimafucin is a potent antifungal agent from the group of polyene macrolide antibiotics. The active ingredient of the drug blocks the sterols of the fungal cell membrane, which causes their death. The maximum sensitivity of the drug is manifested in relation to the type of fungi Candida spp, and the least - to dermatophytes. At the moment, clinical practice has not revealed the resistance of fungi to natamycin.

Natamycin is not absorbed in the gastrointestinal tract, is not absorbed on the skin and mucous membranes. Various dosage forms of Pimafucin provide a successful fight against fungi in all affected areas.

The remedy belongs to those few drugs that are not prohibited for taking to combat thrush in pregnant women and lactating women, since they do not have a negative effect on the fetus and breast milk.

Indications for use

Pimafucin is used in the presence of the following pathologies:

Mode of application

Depending on the form of release, Pimafucin is used as follows:

1. Tablets (take 1 pc. 4 times a day):

• With candidiasis of the nails (together with the cream) - within 2-3 months;
• With vulvovaginal candidiasis (together with vaginal suppositories for the purpose of sanitizing the candidomycosis focus in the intestine) - within 10-20 days;
• In the case of intestinal candidiasis (children 1 tab. 2 times a day) - within a week;
• With onychomycosis (together with Pimafucin cream) - within 2-3 months.

2. Cream:

• With dermacomycosis (including with lesions of the skin or nails), the affected area is smeared with cream 1-4 times a day. The course of treatment lasts 2-3 weeks;
• When treating candidal lesions with a partner, the drug is applied to the anogenital zone (for fungal diseases of the intestine, along with taking Pimafucin tablets).

3. Suppositories used in the case of vulvovaginal candidiasis, 1 pc. deeply inserting into the vagina before going to bed 1 time a day (the introduction is made in the supine position). The course of treatment is determined individually (usually 3-6 days). Intravaginal administration lasts 2-3 days after the disappearance of external signs.

After administration, suppositories quickly melt from body temperature with the formation of a volumetric foaming mass, which improves the distribution of the drug along the walls of the vagina.

When treating with suppositories, it is not necessary to interrupt sex. At the onset of critical days, the administration of the drug is suspended.

After the signs of candidiasis disappear, you should not immediately abandon the use of Pimafucin, since the fungus may not be completely destroyed. The tablets are taken for at least 2-3 days. after the signs of the disease leave (burning, itching, the presence of curdled clots).

The most acceptable solution is to consult a doctor, who, after prescribing certain tests, will determine the advisability of further taking the drug or discontinuing it.

Release form, composition

Pimafucin, depending on the form of release, has the following composition:

1. Tablets - round, white, enteric coated, placed in a dark glass bottle, which include:

• The active ingredient is natamycin (100 mg);
• Auxiliary - magnesium stearic acid, polyvinylpyrrolidone, starch, lactose, talc, gelatin, gum arabic, kaolin, methyl parahydroxybenzoate, titanium dioxide, triacetin, beeswax, acetate phthalcellulose, sugar.

2. Cream of white or light yellow color in tubes of 30 g, 1 g of which contains:

• The active ingredient is natamycin (20 mg);
• Auxiliary: propylene glycol, diceloleate, cetostearic alcohol, sodium lauryl sulfate, propyl parahydroxybenzoate, cetyl ether.

3. Vaginal suppositories of oblong shape, white or yellow shade, each of which contains:

• The active ingredient is natamycin (100 mg);
• Auxiliary - cetyl alcohol, sorbitan trioleate, sodium bicarbonate, polysorbitol 80, adipic acid, solid fat.

Interaction with other drugs

At the moment, there are no facts of interaction of Pimafucin with other drugs.

2. Side effects

After using Pimafucin, some side effects may appear:

• Signs of allergies in the form of itching and burning, irritation in the genital area after the administration of the suppository;
• Indigestion, diarrhea;

Overdose

Severe cases of overdose with Pimafucin in medical practice have not been registered, but doctors do not exclude the risk of side symptoms if the dosage of the drug is exceeded. On the part of the digestive system, vomiting or painful sensations of various localization may occur. In some cases, an overdose can cause hypersensitivity to the medication.

Contraindications

Pimafucin has no contraindications, but before starting use, you should pay attention to the following restrictions:

• Suppositories can be used by girls starting only from the age of 16;
• It is forbidden to use tablets for the treatment of candidiasis in newborns (there are special suspensions for this).

During pregnancy

3. Special instructions

Influence on the ability to drive vehicles and control mechanisms

Pimafucin does not have the ability to disrupt psychomotor reactions or affect the nervous system.

Pregnancy and lactation

Pimafucin can be taken at any stage of pregnancy. There is no potential harm to the fetus. If it is necessary to take the drug during lactation, additional consultation with a doctor is required.

Childhood use

Pimafucin is used in pediatric practice only on the basis of the testimony of a specialist (no age restrictions were noted for the drug).

With impaired renal function

There are no special instructions in the instructions.

For violations of liver function

There is no need to adjust the course of therapy.

Conditions of dispensing from pharmacies

OTC sale.

4. Conditions and terms of storage

The medicine in a whole package is stored at tо up to 25оС, avoiding direct sunlight, for 2 years.

Pimafucin is an antifungal drug that belongs to the macrolide group and has a fungicidal effect.

The active substance of the drug is natamycin. The drug is used for various fungal diseases of the skin, nails, vulvovaginal candidiasis, fungal diseases of the gastrointestinal tract. The drug can be used during pregnancy.

In this article, we will consider why doctors prescribe the drug Pimafucin, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Pimafucin, leave feedback in the comments.

Composition and form of release

Clinical and pharmacological group: antifungal antibiotic.

1. 1 tablet of Pimafucin contains 100 mg of active ingredient and auxiliary components (potato starch, magnesium stearate, PVP, lactose, gelatin, calcium carbonate, kaolin, talc, triacetin, cellulose acetate phthalate, beeswax, titanium oxide, sucrose). Pimafucin enteric-coated tablets are produced, in vials of 20 tablets along with instructions for use.
2. 1 vaginal suppository contains 100 mg of natamycin, as well as auxiliary components (cetyl alcohol, solid fat, polysorbate, sorbitol, sodium bicarbonate, adipic acid). Pimafucin suppositories are produced in a contoured cell-free package of 3 suppositories. In a cardboard box 1 or 2 packages.
3. Pimafucin cream is intended for external use. 1 g of cream contains 20 mg of natamycin, as well as auxiliary components (decyloleate, cetostearyl alcohol, wax, sodium lauryl sulfate, propylene glycol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, water). The cream is produced in tubes of 30 g, in a cardboard box 1 tube with instructions for use.

What is Pimafucin used for?

For cream - fungal diseases of the mucous membranes and skin caused by pathogens sensitive to natamycin, including:

1. Candidiasis of the skin and nails;
2. Dermatomycosis;
3. Otitis externa caused by fungi or complicated by candidiasis;
4. Vulvitis, vaginitis, balanoposthitis, vulvovaginitis caused by Candida.

For suppositories- fungal diseases of the mucous membranes of the genital organs, caused mainly by fungi of the genus Candida:

1. Vulvitis;
2. Vaginitis;
3. Vulvovaginitis.

For tablets:

1. Intestinal candidiasis;
2. Candidiasis of the skin and mucous membranes (including vulvitis, candidal vaginitis and vulvovaginitis) - to sanitize the intestinal reservoir of Candida fungi.
3. Acute atrophic and acute pseudomembranous candidiasis with immune deficiency or cachexia, as well as after therapy with cytostatics, antibiotics or corticosteroids;

pharmachologic effect

Antifungal polyene antibiotic of the macrolide group with a wide spectrum of action. The drug is active against yeast (Torulopsis, Rhoduturola), yeast-like fungi (Candida albicans), dermatomycetes (Trichophyton, Microsporum, Epidermophyton), other pathogenic fungi (Aspergillus, Penicillium), as well as Trichomonas.

Has a fungicidal effect. Pimafucin binds sterols of cell membranes, disrupting their integrity and function, which leads to the death of microorganisms. Dermatophytes are less sensitive to natamycin, but natamycin resistance is not found in clinical practice. Not absorbed from the gastrointestinal tract, skin and mucous membranes.

Instructions for use

The drug is taken orally. Food intake does not affect the effectiveness of the drug.

• With a persistent course of vaginitis caused by fungi of the genus Candida, together with local antifungal drugs (for example, Pimafucin suppositories), Pimafucin tablets are used to sanitize the focus of candidal infection in the intestine (100 mg orally (1 tab.) 4 times / day for 10-20 days).
• In case of intestinal candidiasis, adults are recommended to take 100 mg (1 tab.) 4 times / day, children - 100 mg (1 tab.) 2 times / day. The average duration of the course of treatment is 1 week.
• Vaginal suppositories are prescribed for women with vulvitis, vulvovaginitis, vaginitis. The drug is injected as deep as possible, in the supine position. The procedure is recommended to be done before going to bed for three to six days, using 1 suppository per day. With a persistent course of candidal vaginitis, in addition to suppositories, Pimafucin tablets are prescribed, which are taken from 10 to 20 days. Dosage - 4 tablets daily at regular intervals.
• Instructions for the cream. It is applied externally. On the affected areas from one to several times a day, the ointment should be applied for balanoposthitis, vulvovaginitis and vulvitis. If symptoms persist, suppositories or pills are prescribed. For dermatomycosis (including diaper rash in children and candidiasis of nails and skin), the suspension should be applied to the nails and skin up to 4 times a day.

The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for several more days.

Contraindications

Pimafucin is contraindicated for use by persons with hypersensitivity to any ingredient of the drug. Patients suffering from galactose or fructose intolerance, glucose-galactose malabsorption need to remember that the tablets contain lactose monohydrate and sucrose. All dosage forms of the drug are approved for use during pregnancy and breastfeeding.

Side effects

When using tablets: nausea and diarrhea (usually occur in the first days of treatment and go away on their own with continued therapy). When applying cream and suppositories: burning sensation, slight irritation.

Pregnancy and lactation

It is possible to use Pimafucin during pregnancy and lactation.

special instructions

Vaginal suppositories under the influence of body temperature quickly dissolve, forming a foamy mass, which contributes to the uniform distribution of the active substance.

In the case of a chronic or recurrent infection, topical treatment can be supplemented with pills and a cream. Ethanol, which is part of vaginal suppositories, can cause hypersensitivity reactions. During menstruation, suppository therapy is interrupted.

During the period of treatment with suppositories, there is no need to exclude sexual intercourse. However, it is recommended to conduct an examination of the sexual partners and, if a candidal lesion is detected, to conduct a course of treatment with Pimafucin. You should also provide for the use of barrier contraceptives during the treatment period.

Analogs

• Analogs of tablets: drugs Alpha Normix and Nystatin-Health.
• Analogs in the form of suppositories: Nystatin, Livarol, Clotrimazole. The price of candle analogs is from 37 to 320 rubles.

Pimafucin has a cheaper analogue - Nystatin, a domestic drug that is similar in action.

Prices

The average price of PIMAFUCIN tablets in pharmacies (Moscow) is 400 rubles. Candles 260 rubles. Cream 250 rubles.

Conditions of dispensing from pharmacies

The drug is approved for use as a means of OTC.